Literature summary extracted from

Kucerova, L.; Matuskova, M.; Hlubinova, K.; Bohovic, R.; Feketeova, L.; Janega, P.; Babal, P.; Poturnajova, M.
Bystander cytotoxicity in human medullary thyroid carcinoma cells mediated by fusion yeast cytosine deaminase and 5-fluorocytosine (2011), Cancer Lett., 311, 101-112.

Application

EC Number	Application	Comment	Organism
3.5.4.1	medicine	efficiency of gene-directed enzyme/prodrug therapy (GDEPT) based on combination of fusion yeast cytosine deaminase (yCD) and 5-fluorocytosine (5FC) on model human medullary thyroid carcinoma (MTC) cell line TT is determined. Significant bystander effect is shown in vitro and 5-fluorocytosine administration results in potent antitumor effect in vivo. In addition high efficiency of cell-mediated GDEPT is shown, when human mesenchymal stromal cells are used as delivery vehicles in direct cocultures in vitro	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.4.1	Saccharomyces cerevisiae	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.4.1	5-fluorocytosine + H2O	-	Saccharomyces cerevisiae	5-fluorouracil + NH3	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.4.1	yCD	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)