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Literature summary extracted from

  • Lueddeke, F.; Dikfidan, A.; Harder, J.
    Physiology of deletion mutants in the anaerobic beta-myrcene degradation pathway in Castellaniella defragrans (2012), BMC Microbiol., 12, 192.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.127 additional information generation of an in-frame deletion mutants Castellaniella defragrans DELTAldi Castellaniella defragrans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.127 beta-myrcene + H2O Castellaniella defragrans
-
 (3S)-linalool
-
 ?
4.2.1.127 beta-myrcene + H2O Castellaniella defragrans 65Phen
-
 (3S)-linalool
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.86 Castellaniella defragrans
-
-
-
1.2.1.86 Castellaniella defragrans 65Phen
-
-
-
4.2.1.127 Castellaniella defragrans E1XUJ2 i.e. Alcaligenes defragrans, gene ldi
-
4.2.1.127 Castellaniella defragrans 65Phen E1XUJ2 i.e. Alcaligenes defragrans, gene ldi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.86 geranial + H2O + NAD+
-
 Castellaniella defragrans geranate + NADH + H+
-
 ?
1.2.1.86 geranial + H2O + NAD+
-
 Castellaniella defragrans 65Phen geranate + NADH + H+
-
 ?
4.2.1.127 beta-myrcene + H2O
-
 Castellaniella defragrans (3S)-linalool
-
 ?
4.2.1.127 beta-myrcene + H2O
-
 Castellaniella defragrans 65Phen (3S)-linalool
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.86 GADH
-
 Castellaniella defragrans
1.2.1.86 geoB
-
 Castellaniella defragrans
4.2.1.127 LDI
-
 Castellaniella defragrans
4.2.1.127 ldi/LDI
-
 Castellaniella defragrans
4.2.1.127 linalool dehydratase-isomerase
-
 Castellaniella defragrans

General Information

EC Number General Information Comment Organism
1.2.1.86 metabolism the enzyme contributes to the formation of geranic acid Castellaniella defragrans
4.2.1.127 malfunction deletion of gene ldi affects growth on acyclic monoterpenes, e.g. beta-myrcene, phenotype, overview Castellaniella defragrans
4.2.1.127 metabolism the bifunctional linalool dehydratase-isomerase ldi/LDI is the initial enzyme in the anaerobic beta-myrcene degradation pathway and catalyzes the hydration of beta-myrcene to (S)-(+)-linalool and its isomerization to geraniol. A high-affinity geraniol dehydrogenase geoA/GeDH and a geranial dehydrogenase geoB/GaDH contribute to the formation of geranic acid Castellaniella defragrans
4.2.1.127 additional information growth on cyclic monoterpenes independent of the initial enzyme linalool dehydratase suggests the presence of a second enzyme system activating unsaturated hydrocarbons Castellaniella defragrans
4.2.1.127 physiological function essential requirement of the linalool dehydratase-isomerase for growth on acyclic monoterpenes, e.g. beta-myrcene, but not on cyclic monoterpenes, e.g. cyclic alpha-phellandrene or limonene Castellaniella defragrans