Literature summary extracted from

Zhou, M.; Dong, X.; Baldauf, C.; Chen, H.; Zhou, Y.; Springer, T.A.; Luo, X.; Zhong, C.; Graeter, F.; Ding, J.
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 (2011), Blood, 117, 4623-4631.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	Homo sapiens	cleavage occurs at strand beta4 (Tyr1605-Met1606) in the structural core of the A2 domain. Ca2+ binding stabilizes the A2 domain and impedes its unfolding, and consequently protects it from cleavage by ADAMTS13	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.87	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	cleavage occurs at strand beta4 (Tyr1605-Met1606) in the structural core of the A2 domain. Ca2+ binding stabilizes the A2 domain and impedes its unfolding, and consequently protects it from cleavage by ADAMTS13	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.87	ADAMTS13	-	Homo sapiens

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Release 2023.1 (January 2023)