EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.98 | (E)-N1-hydroxy-N5-(5-styryl-1,3,4-thiadiazol-2-yl)glutaramide | antiproliferative activities against MDA-MB-231 and K562 cell lines, IC50 0.0059 and 0.00675 microM, respectively | Homo sapiens | |
3.5.1.98 | additional information | presence of 5-6 carbon units between the Zn2+ binding group and the 1,3,4-thiadiazole ring is optimal for inhibitory potency | Homo sapiens | |
3.5.1.98 | N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N7-hydroxyheptanediamide | antiproliferative activities against MDA-MB-231 and K562 cell lines, IC50 0.0061 and 0.0122 microM, respectively | Homo sapiens | |
3.5.1.98 | N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N8-hydroxyoctanediamide | antiproliferative activities against MDA-MB-231 and K562 cell lines, IC50 0.00298 and 0.0091 microM, respectively | Homo sapiens | |
3.5.1.98 | N1-hydroxy-N7-(5-phenyl-1,3,4-thiadiazol-2-yl)heptanediamide | antiproliferative activities against MDA-MB-231 and K562 cell lines, IC50 0.0055 and 0.0129 microM, respectively | Homo sapiens | |
3.5.1.98 | N1-hydroxy-N8-(5-phenyl-1,3,4-thiadiazol-2-yl)octanediamide | - |
Homo sapiens | |
3.5.1.98 | suberoylanilide hydroxamic acid | i.e. SAHA, antiproliferative activities against MDA-MB-231 and K562 cell lines, IC50 0.00132 and 0.00169 microM, respectively | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.98 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.98 | HeLa cell | - |
Homo sapiens | - |
3.5.1.98 | K-562 cell | - |
Homo sapiens | - |
3.5.1.98 | MDA-MB-231 cell | - |
Homo sapiens | - |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.1.98 | 0.000089 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | N1-hydroxy-N7-(5-phenyl-1,3,4-thiadiazol-2-yl)heptanediamide | |
3.5.1.98 | 0.00015 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | suberoylanilide hydroxamic acid | |
3.5.1.98 | 0.00016 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | (E)-N1-hydroxy-N5-(5-styryl-1,3,4-thiadiazol-2-yl)glutaramide | |
3.5.1.98 | 0.00022 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N7-hydroxyheptanediamide | |
3.5.1.98 | 0.00026 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N8-hydroxyoctanediamide | |
3.5.1.98 | 0.00027 | - |
HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication | Homo sapiens | N1-hydroxy-N8-(5-phenyl-1,3,4-thiadiazol-2-yl)octanediamide |