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Literature summary extracted from

  • Krakowiak, A.; Pecherzewska, R.; Kaczmarek, R.; Tomaszewska, A.; Nawrot, B.; Stec, W.J.
    Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis (2011), Bioorg. Med. Chem., 19, 5053-5060.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.29 O,O',O''-tris[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O',O''-propane-1,2,3-triyl tris[hydrogen (phosphorothioate)]
-
 Homo sapiens
3.6.1.29 O,O'-bis[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O'-(2-hydroxypropane-1,3-diyl) bis[hydrogen (phosphorothioate)]
-
 Homo sapiens
3.6.1.29 O-[1,11-bis[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-3,9-dioxido-3,9-disulfanyl-2,4,8,10-tetraoxa-3l5,9l5-diphosphaundecan-6-yl] dihydrogen phosphorothioate
-
 Homo sapiens
3.6.1.29 O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] dihydrogen phosphorothioate
-
 Homo sapiens
3.6.1.29 O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] O-[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] hydrogen phosphorothioate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.29 Homo sapiens P49789
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.29 HEK-293T cell
-
 Homo sapiens
-
3.6.1.29 HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.29 P1,P3-bis(5'-adenosyl)triphosphate + H2O major substrate Homo sapiens AMP + ADP
-
 ?
3.6.1.29 P1,P4-bis(5'-adenosyl)tetraphosphate + H2O major substrate Homo sapiens AMP + ATP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.29 Fhit
-
 Homo sapiens
3.6.1.29 fragile histidine triad
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.6.1.29 physiological function formation of Fhit-substrate complex results in an apoptosis initiation signal while subsequent hydrolysis of ApnA terminates this action Homo sapiens