BRENDA - Enzyme Database

Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis

Krakowiak, A.; Pecherzewska, R.; Kaczmarek, R.; Tomaszewska, A.; Nawrot, B.; Stec, W.J.; Bioorg. Med. Chem. 19, 5053-5060 (2011)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.29
O,O',O''-tris[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O',O''-propane-1,2,3-triyl tris[hydrogen (phosphorothioate)]
-
Homo sapiens
3.6.1.29
O,O'-bis[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O'-(2-hydroxypropane-1,3-diyl) bis[hydrogen (phosphorothioate)]
-
Homo sapiens
3.6.1.29
O-[1,11-bis[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-3,9-dioxido-3,9-disulfanyl-2,4,8,10-tetraoxa-3l5,9l5-diphosphaundecan-6-yl] dihydrogen phosphorothioate
-
Homo sapiens
3.6.1.29
O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] dihydrogen phosphorothioate
-
Homo sapiens
3.6.1.29
O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] O-[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] hydrogen phosphorothioate
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.29
Homo sapiens
P49789
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.29
HEK-293T cell
-
Homo sapiens
-
3.6.1.29
HL-60 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.29
P1,P3-bis(5'-adenosyl)triphosphate + H2O
major substrate
719088
Homo sapiens
AMP + ADP
-
-
-
?
3.6.1.29
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
major substrate
719088
Homo sapiens
AMP + ATP
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.29
O,O',O''-tris[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O',O''-propane-1,2,3-triyl tris[hydrogen (phosphorothioate)]
-
Homo sapiens
3.6.1.29
O,O'-bis[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O'-(2-hydroxypropane-1,3-diyl) bis[hydrogen (phosphorothioate)]
-
Homo sapiens
3.6.1.29
O-[1,11-bis[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-3,9-dioxido-3,9-disulfanyl-2,4,8,10-tetraoxa-3l5,9l5-diphosphaundecan-6-yl] dihydrogen phosphorothioate
-
Homo sapiens
3.6.1.29
O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] dihydrogen phosphorothioate
-
Homo sapiens
3.6.1.29
O-[3-[[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]-2,2-bis([[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy](sulfanyl)phosphoryl]oxy]methyl)propyl] O-[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] hydrogen phosphorothioate
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.29
HEK-293T cell
-
Homo sapiens
-
3.6.1.29
HL-60 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.29
P1,P3-bis(5'-adenosyl)triphosphate + H2O
major substrate
719088
Homo sapiens
AMP + ADP
-
-
-
?
3.6.1.29
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
major substrate
719088
Homo sapiens
AMP + ATP
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.6.1.29
physiological function
formation of Fhit-substrate complex results in an apoptosis initiation signal while subsequent hydrolysis of ApnA terminates this action
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.6.1.29
physiological function
formation of Fhit-substrate complex results in an apoptosis initiation signal while subsequent hydrolysis of ApnA terminates this action
Homo sapiens