EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.180 | overexpressed in Escherichia coli DH10B cells using the pET30 vector, selenomethionine-substituted protein expressed in Escherichia coli BL21(DE3) | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | 1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea | - |
Escherichia coli | |
2.3.1.180 | 1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea | - |
Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Escherichia coli | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.180 | to homogeneity in three chromatographic steps (Q-Sepharose, MonoQ, and hydroxyapatite) | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | malonyl-ACP + acetyl-CoA | - |
Escherichia coli | CO2 + CoA + acetoacetyl-ACP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-acyl carrier protein synthase III | - |
Escherichia coli |
2.3.1.180 | FabH | - |
Escherichia coli |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.180 | 0.0047 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea | |
2.3.1.180 | 0.0066 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea | |
2.3.1.180 | 0.0101 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea | |
2.3.1.180 | 0.0218 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea | |
2.3.1.180 | 0.0374 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea | |
2.3.1.180 | 0.041 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea | |
2.3.1.180 | 0.0515 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea | |
2.3.1.180 | 0.0564 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea | |
2.3.1.180 | 0.0717 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea |