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Literature summary extracted from
- beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (2011), Bioorg. Med. Chem., 19, 2378-2391.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.6.1.23 | expressed in Escherichia coli BL21(DE3) cells | Plasmodium falciparum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | 1-(2-amido-4-trityloxybutyl)uracil | - |
Plasmodium falciparum |  |
| 3.6.1.23 | 1-(2-dimethylamido-4-trityloxybutyl)uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-(2-morpholinamido-4-trityloxybutyl)uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(acetamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(acetamido)-4-(triphenylmethyl)aminobutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(carbobenzoxymethyl)-4-(triphenylmethyl)aminobutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(carboethoxyethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(carboxy)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(carboxy)-4-(triphenylmethyl)aminobutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(carboxyethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(diethylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(ethylamido)-4-(tert-butyldiphenylsilyloxy) butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(hydroxyethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(methoxyethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(methylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(N,N-dimethylaminoethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(N-benzyloxycarbonylpiperazinamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(N-methylpiperazine)amido-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
| 3.6.1.23 | 1-[2-(tert-butyldiphenylsilyloxyethylamido)-4-trityloxybutyl]uracil | - |
Plasmodium falciparum | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | Plasmodium falciparum | - |
dUMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | Plasmodium falciparum | Q8II92 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.23 | phosphocellulose column chromatography and Superdex 200 gel filtration | Plasmodium falciparum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | - |
Plasmodium falciparum | dUMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | deoxyuridine-5'-triphosphate nucleotidohydrolase | - |
Plasmodium falciparum |
| 3.6.1.23 | dUTPase | - |
Plasmodium falciparum |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.6.1.23 | 0.0002 | - |
1-[2-(carboxyethylamido)-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0004 | - |
1-[2-(hydroxyethylamido)-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0005 | - |
1-[2-(carboethoxyethylamido)-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0013 | - |
1-(2-amido-4-trityloxybutyl)uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0014 | - |
1-[2-(methoxyethylamido)-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0016 | - |
1-[2-(carboxy)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0021 | - |
1-(2-morpholinamido-4-trityloxybutyl)uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0027 | - |
1-(2-dimethylamido-4-trityloxybutyl)uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0036 | - |
1-[2-(methylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.005 | - |
1-[2-(acetamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0055 | - |
1-[2-(acetamido)-4-(triphenylmethyl)aminobutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0056 | - |
1-[2-(N-methylpiperazine)amido-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0057 | - |
1-[2-(ethylamido)-4-(tert-butyldiphenylsilyloxy) butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0065 | - |
1-[2-(carbobenzoxymethyl)-4-(triphenylmethyl)aminobutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0072 | - |
1-[2-(carboxy)-4-(triphenylmethyl)aminobutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.0078 | - |
1-[2-(N,N-dimethylaminoethylamido)-4-trityloxybutyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.01 | - |
1-[2-(tert-butyldiphenylsilyloxyethylamido)-4-trityloxybutyl]uracil | Ki above 0.01 mM, pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.02 | - |
1-[2-(diethylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
| 3.6.1.23 | 0.098 | - |
1-[2-(N-benzyloxycarbonylpiperazinamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil | pH and temperature not specified in the publication | Plasmodium falciparum | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | physiological function | the enzyme is involved in nucleotide metabolism that acts as first line of defence against uracil incorporation into DNA | Plasmodium falciparum |
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