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Literature summary extracted from

  • Roughley, S.D.; Browne, H.; Macias, A.T.; Benwell, K.; Brooks, T.; D'Alessandro, J.; Daniels, Z.; Dugdale, S.; Francis, G.; Gibbons, B.; Hart, T.; Haymes, T.; Kennett, G.; Lightowler, S.; Matassova, N.; Mansell, H.; Merrett, A.; Misra, A.; Padfield, A.; Parsons, R.; Pratt, R.; Robertson, A.; Simmonite, H.; Tan, K.; Walls, S.B.; Wong, M.
    Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity (2012), Bioorg. Med. Chem. Lett., 22, 901-906.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.99 (1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Homo sapiens
3.5.1.99 (1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Rattus norvegicus
3.5.1.99 (4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Homo sapiens
3.5.1.99 (4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Rattus norvegicus
3.5.1.99 1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
Homo sapiens
3.5.1.99 1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
Rattus norvegicus
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Homo sapiens
3.5.1.99 azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Rattus norvegicus
3.5.1.99 azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Homo sapiens
3.5.1.99 azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
Rattus norvegicus
3.5.1.99 additional information tetra-substituted azetidine ureas with in vivo activity as fatty acid amide hydrolase inhibitors, overview Homo sapiens
3.5.1.99 additional information tetra-substituted azetidine ureas with in vivo activity as fatty acid amide hydrolase inhibitors, overview Rattus norvegicus
3.5.1.99 N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Homo sapiens
3.5.1.99 N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
Rattus norvegicus
3.5.1.99 VER-156084 a tetrasubstituted azetidine urea FAAH inhibitor Homo sapiens
3.5.1.99 VER-156084 a tetrasubstituted azetidine urea FAAH inhibitor Rattus norvegicus
3.5.1.99 [3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
Rattus norvegicus
3.5.1.99 [3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus
3.5.1.99 [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Homo sapiens
3.5.1.99 [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.99 microsome
-
Homo sapiens
-
-
3.5.1.99 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.99 anandamide + H2O Homo sapiens i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
?
3.5.1.99 anandamide + H2O Rattus norvegicus i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.99 Homo sapiens
-
-
-
3.5.1.99 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.99 anandamide + H2O i.e. arachidonoyl ethanolamide Homo sapiens arachidonic acid + ethanolamine
-
?
3.5.1.99 anandamide + H2O i.e. arachidonoyl ethanolamide Rattus norvegicus arachidonic acid + ethanolamine
-
?
3.5.1.99 arachidonoyl 7-amido-4-methylcoumarin + H2O
-
Homo sapiens arachidonic acid + 7-amino-4-methylcoumarin
-
?
3.5.1.99 arachidonoyl 7-amido-4-methylcoumarin + H2O
-
Rattus norvegicus arachidonic acid + 7-amino-4-methylcoumarin
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.99 FAAH
-
Homo sapiens
3.5.1.99 FAAH
-
Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.99 0.000094
-
pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
3.5.1.99 0.000126
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
3.5.1.99 0.000161
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
3.5.1.99 0.000237
-
pH and temperature not specified in the publication Rattus norvegicus (1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.00037
-
pH and temperature not specified in the publication Rattus norvegicus (4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.000375
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000388
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
3.5.1.99 0.000413
-
pH and temperature not specified in the publication Rattus norvegicus [3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000423
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
3.5.1.99 0.000447
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000464
-
pH and temperature not specified in the publication Rattus norvegicus 1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
3.5.1.99 0.000471
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000505
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
3.5.1.99 0.000537
-
pH and temperature not specified in the publication Homo sapiens (1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.000556
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000647
-
pH and temperature not specified in the publication Rattus norvegicus azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.000681
-
pH and temperature not specified in the publication Rattus norvegicus 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
3.5.1.99 0.000713
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000715
-
pH and temperature not specified in the publication Rattus norvegicus [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.000854
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
3.5.1.99 0.000937
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00109
-
pH and temperature not specified in the publication Homo sapiens (4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.00148
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
3.5.1.99 0.00209
-
pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
3.5.1.99 0.00225
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
3.5.1.99 0.00248
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
3.5.1.99 0.00263
-
pH and temperature not specified in the publication Rattus norvegicus azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.00288
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.00312
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
3.5.1.99 0.00332
-
pH and temperature not specified in the publication Homo sapiens [3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00364
-
pH and temperature not specified in the publication Rattus norvegicus [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00399
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
3.5.1.99 0.00453
-
pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
3.5.1.99 0.00458
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
3.5.1.99 0.00501
-
pH and temperature not specified in the publication Homo sapiens [3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00503
-
pH and temperature not specified in the publication Homo sapiens 1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
3.5.1.99 0.00504
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
3.5.1.99 0.0051
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
3.5.1.99 0.00524
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.00531
-
pH and temperature not specified in the publication Rattus norvegicus 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
3.5.1.99 0.00541
-
pH and temperature not specified in the publication Rattus norvegicus N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.00542
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00654
-
pH and temperature not specified in the publication Homo sapiens 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
3.5.1.99 0.00669
-
pH and temperature not specified in the publication Homo sapiens [3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00682
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
3.5.1.99 0.00717
-
pH and temperature not specified in the publication Homo sapiens [3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00739
-
pH and temperature not specified in the publication Homo sapiens [3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.00809
-
pH and temperature not specified in the publication Homo sapiens [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.0096
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.0111
-
pH and temperature not specified in the publication Homo sapiens azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.0115
-
pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.0164
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
3.5.1.99 0.0174
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
3.5.1.99 0.0184
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.0247
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
3.5.1.99 0.0279
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
3.5.1.99 0.0286
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
3.5.1.99 0.0297
-
pH and temperature not specified in the publication Rattus norvegicus 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
3.5.1.99 0.0366
-
pH and temperature not specified in the publication Homo sapiens [3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.037
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.0408
-
pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
3.5.1.99 0.042
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.0624
-
pH and temperature not specified in the publication Homo sapiens 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
3.5.1.99 0.0705
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
3.5.1.99 0.0829
-
pH and temperature not specified in the publication Homo sapiens [3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.0988
-
pH and temperature not specified in the publication Homo sapiens azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
3.5.1.99 0.124
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
3.5.1.99 0.132
-
above, pH and temperature not specified in the publication Homo sapiens [3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.135
-
pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.14
-
pH and temperature not specified in the publication Rattus norvegicus 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
3.5.1.99 0.193
-
pH and temperature not specified in the publication Homo sapiens 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
3.5.1.99 0.206
-
pH and temperature not specified in the publication Homo sapiens [3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.242
-
pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens [3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus [3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus [3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens [3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens 3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Homo sapiens [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.5
-
above, pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
3.5.1.99 0.531
-
pH and temperature not specified in the publication Rattus norvegicus [3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
3.5.1.99 0.887
-
pH and temperature not specified in the publication Homo sapiens N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide