EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.180 | overexpressed in Escherichia coli DH10B cells using the pET30 vector, selenomethionine-substituted protein expressed in Escherichia coli BL21(DE3) | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | 2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | - |
Escherichia coli | |
2.3.1.180 | 2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | - |
Escherichia coli | |
2.3.1.180 | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole | - |
Escherichia coli | |
2.3.1.180 | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | - |
Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Escherichia coli | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.180 | to homogeneity in three chromatographic steps (Q-Sepharose, MonoQ, and hydroxyapatite), immobilized metal ion affinity chromatography (Ni2+) | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | malonyl-ACP + acetyl-CoA | - |
Escherichia coli | CO2 + CoA + acetoacetyl-ACP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-acyl carrier protein synthase III | - |
Escherichia coli |
2.3.1.180 | FabH | - |
Escherichia coli |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.180 | 0.0046 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0084 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | |
2.3.1.180 | 0.0097 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0109 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0136 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | |
2.3.1.180 | 0.0157 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole | |
2.3.1.180 | 0.0184 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | |
2.3.1.180 | 0.0197 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole | |
2.3.1.180 | 0.0223 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0233 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0271 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one | |
2.3.1.180 | 0.0306 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole | |
2.3.1.180 | 0.0899 | - |
pH 7.0, temperature not specified in the publication | Escherichia coli | 2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one |