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Literature summary extracted from

  • Zhao, H.; de Carvalho, L.P.; Nathan, C.; Ouerfelli, O.
    A protecting group-free synthesis of deazathiamine: a step toward inhibitor design (2010), Bioorg. Med. Chem. Lett., 20, 6472-6474.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.5 deazathiamine
-
 Mycobacterium tuberculosis
2.2.1.5 deazathiamine diphosphate binds 32fold more tightly to the enzyme than thiamine diphosphate Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.5 Mycobacterium tuberculosis
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.2.1.5 0.0067
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis deazathiamine diphosphate
2.2.1.5 0.144
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis deazathiamine