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Literature summary extracted from

  • Zhao, C.; Li, P.; Deng, Z.; Ou, H.Y.; McGlinchey, R.P.; OHagan, D.
    Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants (2012), Bioorg. Chem., 44, 1-7.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.8 Streptomyces cattleya F8JMF0 gene is located on the megaplasmid
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2.2.1.8 Streptomyces cattleya DSM 46488 F8JMF0 gene is located on the megaplasmid
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2.5.1.63 Streptomyces cattleya F8JPG4
-
-
2.5.1.63 Streptomyces cattleya DSM 46488 F8JPG4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.8 fluoroacetaldehyde + L-threonine
-
 Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
 ?
2.2.1.8 fluoroacetaldehyde + L-threonine
-
 Streptomyces cattleya DSM 46488 acetaldehyde + 4-fluoro-L-threonine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.63 fluorinase
-
 Streptomyces cattleya

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.8 pyridoxal 5'-phosphate
-
 Streptomyces cattleya

General Information

EC Number General Information Comment Organism
2.2.1.8 physiological function gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase Streptomyces cattleya
2.5.1.63 physiological function enzyme is essential for fluorometabolite production. Addition of 5'-fluoro-5'-deoxyadenosine to culture broth restores fluorometabolite production in the knockout mutant after a 48 h incubation, consistent with the metabolite supplementation by-passing knockout Streptomyces cattleya