EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.66 | 2,6-dibromophenol | competitive | Sphingobium chlorophenolicum | |
1.13.11.66 | 3-bromocatechol | inactivation | Sphingobium chlorophenolicum | |
1.13.11.66 | ortho-disubstituted phenols | - |
Sphingobium chlorophenolicum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.66 | 0.0013 | - |
2,6-dibromohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.0032 | - |
2,6-dichlorohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.0044 | - |
2-chloro-6-methylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.0085 | - |
bromohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.01 | - |
chlorohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.021 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,2-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.041 | - |
methylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.055 | - |
2,6-dimethylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.07 | - |
O2 | cosubstrate 2,6-dimethylhydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.12 | - |
O2 | cosubstrate 2,6-dibromohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.19 | - |
O2 | cosubstrate 2,6-dichlorohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 0.26 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,6-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.66 | Sphingobium chlorophenolicum | Q9ZBB0 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.66 | 2,6-dibromohydroquinone + O2 | - |
Sphingobium chlorophenolicum | 2-bromomaleylacetate + Br- | - |
? | |
1.13.11.66 | 2,6-dichlorohydroquinone + O2 | complete conversion of substrate | Sphingobium chlorophenolicum | 2-chloromaleylacetate + Cl- | - |
? | |
1.13.11.66 | 2,6-dimethylhydroquinone + O2 | - |
Sphingobium chlorophenolicum | 2-methylmaleylacetone + ? | - |
? | |
1.13.11.66 | 2-chloro-6-methylhydroquinone | - |
Sphingobium chlorophenolicum | ? | complete conversion of substrate, yields a mixture of 1,2- and 1,6-cleavage products. The two modes of cleavage have different Km values for oxygen, consistent with a mechanism in which the substrate binds in two catalytically productive orientations | ? | |
1.13.11.66 | bromohydroquinone + O2 | - |
Sphingobium chlorophenolicum | maleylacetate + Br- | - |
? | |
1.13.11.66 | chlorohydroquinone + O2 | - |
Sphingobium chlorophenolicum | maleylacetate + Cl- | - |
? | |
1.13.11.66 | methylhydroquinone + O2 | - |
Sphingobium chlorophenolicum | maleylacetone + ? | - |
? | |
1.13.11.66 | additional information | exhibits a high degree of substrate specificity for 2,6-disubstituted hydroquinones, with halogens greatly preferred at those positions. The asymmetric substrate 2-chloro-6-methylhydroquinone yields a mixture of 87% 1,2-cleavage and 13% 1,6-cleavage products with different Km values for oxygen, consistent with a mechanism in which the substrate binds in two catalytically productive orientations. Monosubstituted hydroquinones show a limited amount of ring cleavage but rapidly inactivate the enzyme in an O2-dependent fashion, suggesting that oxidation of the Fe(II) may be the cause | Sphingobium chlorophenolicum | ? | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.66 | 1.25 | - |
2,6-dimethylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1.4 | - |
O2 | cosubstrate 2,6-dimethylhydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1.6 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,2-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1.61 | - |
2,6-dibromohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1.8 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,6-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 2.2 | - |
O2 | cosubstrate 2,6-dibromohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 2.41 | - |
2-chloro-6-methylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 3.05 | - |
2,6-dichlorohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 4.8 | - |
O2 | cosubstrate 2,6-dichlorohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.66 | 0.7 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,6-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 7 | - |
O2 | cosubstrate 2-chloro-6-methylhydroquinone, 1,2-cleavage, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 19 | - |
O2 | cosubstrate 2,6-dibromohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 20 | - |
O2 | cosubstrate 2,6-dimethylhydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 23 | - |
2,6-dimethylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 26 | - |
O2 | cosubstrate 2,6-dichlorohydroquinone, pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 540 | - |
2-chloro-6-methylhydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1000 | - |
2,6-dichlorohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum | |
1.13.11.66 | 1200 | - |
2,6-dibromohydroquinone | pH 7.0, 23°C | Sphingobium chlorophenolicum |