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Literature summary extracted from

  • Moomaw, A.S.; Maguire, M.E.
    Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation (2010), Biochemistry, 49, 5998-6008.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
7.2.2.14 E281A the mutant shows no significant changes in apparent Mg2+ affinity Salmonella enterica
7.2.2.14 E281K/K287E the apparent cation affinity of the double mutant is identical to that of wild type enzyme Salmonella enterica
7.2.2.14 E281L the mutant shows no significant changes in apparent Mg2+ affinity Salmonella enterica
7.2.2.14 E281Q the mutant shows no significant changes in apparent Mg2+ affinity Salmonella enterica
7.2.2.14 E281R the mutant shows no significant changes in apparent Mg2+ affinity Salmonella enterica
7.2.2.14 E285A non-functional mutant Salmonella enterica
7.2.2.14 E285D non-functional mutant Salmonella enterica
7.2.2.14 E285K non-functional mutant Salmonella enterica
7.2.2.14 E285Q non-functional mutant Salmonella enterica
7.2.2.14 E285R non-functional mutant Salmonella enterica
7.2.2.14 K287E the mutation demonstrates a modest decrease in apparent Mg2+ affinity of 2-4fold, the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold Salmonella enterica
7.2.2.14 K287Q the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold Salmonella enterica
7.2.2.14 K287R the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold Salmonella enterica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.14 Mg2+ a significant part of the selectivity for Mg2+ derives from binding the fully hydrated cation Salmonella enterica

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.14 Salmonella enterica P0A2R8 serovar typhimurium
-

Subunits

EC Number Subunits Comment Organism
7.2.2.14 homopentamer
-
 Salmonella enterica

Synonyms

EC Number Synonyms Comment Organism
7.2.2.14 CorA
-
 Salmonella enterica