Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Saha, S.; Wang, J.; Buckley, B.; Wang, Q.; Lilly, B.; Chernov, M.; Kashina, A.
    Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis (2012), Biochem. Pharmacol., 83, 866-873.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.8 aurothioglucose complete inhibition at 0.003 mM Mus musculus
2.3.2.8 Disulfiram complete inhibition at 0.003 mM Mus musculus
2.3.2.8 merbromin
-
 Mus musculus
2.3.2.8 Reactive blue 2
-
 Mus musculus
2.3.2.8 suramin complete inhibition at 0.001 mM Mus musculus
2.3.2.8 Tannic acid complete inhibition at 0.001 mM Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.8 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.8 L-arginyl-tRNAArg + bovine serum albumin
-
 Mus musculus tRNAArg + L-arginyl-[bovine serum albumin]
-
 ?
2.3.2.8 L-arginyl-tRNAAsp + beta-actin
-
 Mus musculus tRNAAsp + L-arginyl-[beta-actin]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.8 Ate1
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.2.8 0.00028
-
 in 50 mM HEPES pH 7.5, 25 mM KCl, 15 mM MgCl2, 0.1 mM dithiothreitol, at 37°C Mus musculus Tannic acid
2.3.2.8 0.00034
-
 in 50 mM HEPES pH 7.5, 25 mM KCl, 15 mM MgCl2, 0.1 mM dithiothreitol, at 37°C Mus musculus merbromin
2.3.2.8 0.00043
-
 in 50 mM HEPES pH 7.5, 25 mM KCl, 15 mM MgCl2, 0.1 mM dithiothreitol, at 37°C Mus musculus suramin
2.3.2.8 0.00097
-
 in 50 mM HEPES pH 7.5, 25 mM KCl, 15 mM MgCl2, 0.1 mM dithiothreitol, at 37°C Mus musculus Reactive blue 2

General Information

EC Number General Information Comment Organism
2.3.2.8 malfunction impairments of arginyltransferase ATE1 are implicated in congenital heart defects, obesity, cancer, and neurodegeneration Mus musculus
2.3.2.8 physiological function posttranslational arginylation mediated by arginyltransferase (ATE1) is an emerging major regulator of embryogenesis and cell physiology Mus musculus