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Literature summary extracted from

  • Miyayama, T.; Hiraoka, D.; Kawaji, F.; Nakamura, E.; Suzuki, N.; Ogra, Y.
    Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line (2010), Biochem. J., 429, 53-61.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.9 expressed in Hepa 1-6 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.9 cytoplasmic vesicle COMM-domain-containing 1 maintains the amount of Atp7b and facilitates recruitment of the enzyme from cytoplasmic vesicles to the trans-Golgi network membrane Mus musculus 31410
-
7.2.2.9 Golgi apparatus COMM-domain-containing 1 maintains the amount of Atp7b and facilitates recruitment of the enzyme from cytoplasmic vesicles to the trans-Golgi network membrane Mus musculus 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.9 ATP + H2O + Cu+/in Mus musculus
-
 ADP + phosphate + Cu+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.9 Mus musculus Q64446
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.9 HEPA 1-6 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.9 ATP + H2O + cisplatin/in
-
 Mus musculus ADP + phosphate + cisplatin/out
-
 ?
7.2.2.9 ATP + H2O + Cu+/in
-
 Mus musculus ADP + phosphate + Cu+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.9 ATP-dependent copper transporter 7beta
-
 Mus musculus
7.2.2.9 ATP7B
-
 Mus musculus
7.2.2.9 copper transporting ATPase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
7.2.2.9 Mus musculus COMM-domain-containing 1 knockdown reduces the expression of Atp7b, and abolishes the relocation of Atp7b back from the periphery to the trans-Golgi network membrane down