EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.18 | homocysteine | inhibition of the expression of DDAH-2 reduces the NO production induced by IL-1beta | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.3.18 | mitochondrion | conventional immunofluorescence and confocal microscopy reveal the presence of DDAH-2 in the mitochondria of IL-1beta-stimulated chondrocytes. Blocking the translocation to mitochondria reduces the NO production induced by IL-1beta | Homo sapiens | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.18 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.3.18 | cartilage | DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage | Homo sapiens | - |
3.5.3.18 | chondrocyte | - |
Homo sapiens | - |
3.5.3.18 | knee | normal human chondrocytes are isolated from knee cartilage obtained | Homo sapiens | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.18 | DDAH-2 | - |
Homo sapiens |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.5.3.18 | Homo sapiens | DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage | up |
3.5.3.18 | Homo sapiens | in chondrocyte mitochondria extracts, DDAH-2 expression is significantly increased after exposure to IL-1beta | up |