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Literature summary extracted from

  • Libano-Soares, J.D.; Landgraf, S.S.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    Prostaglandin E2 modulates proximal tubule Na+-ATPase activity: cooperative effect between protein kinase A and protein kinase C (2011), Arch. Biochem. Biophys., 507, 281-286.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.3 additional information the addition of 0.001 mM guanosine 5’-O-(2-thiodiphosphate) does not change the enzyme activity Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 Furosemide
-
Sus scrofa
7.2.2.3 prostaglandin E2 dose-dependent inhibition with maximal effect at 1 nM. The addition of 0.001 mM prostaglandin E2 decreases Na+-ATPase activity by 41%. The inhibitory effect of prostaglandin E2 on proximal tubule Na+-ATPase activity involves G protein and the activation of protein kinase A. The protein A-mediated inhibitory effect of prostaglandin E2 on Na+-ATPase activity requires previous activation of protein kinase C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
Sus scrofa 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 renal proximal tubule
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
Sus scrofa ADP + phosphate + Na+/out
-
?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
Sus scrofa