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Literature summary extracted from

  • Mei, G.Y.; Yan, X.X.; Turak, A.; Luo, Z.Q.; Zhang, L.Q.
    AidH, an alpha/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonase (2010), Appl. Environ. Microbiol., 76, 4933-4942.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.81 E219T the mutant is active at wild type levels Ochrobactrum sp. T63
3.1.1.81 G100V inactive Ochrobactrum sp. T63
3.1.1.81 G104V inactive Ochrobactrum sp. T63
3.1.1.81 H248S inactive Ochrobactrum sp. T63
3.1.1.81 S102V inactive Ochrobactrum sp. T63

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.81 Mn2+ the N-acyl-(S)-homoserine lactone-inactivating activity of the enzyme requires Mn2+ Ochrobactrum sp. T63
3.1.1.81 additional information not affected by Ca2+, Mg2+, Cu2+, Fe2+, Zn2+ Ochrobactrum sp. T63

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.81 Ochrobactrum sp. T63 D2J2T6
-
-
3.1.1.81 Ochrobactrum sp. T63 ATCC 49188 D2J2T6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.81 N-acyl-(S)-homoserine lactone + H2O
-
 Ochrobactrum sp. T63 N-acyl-(S)-homoserine
-
 ?
3.1.1.81 N-acyl-(S)-homoserine lactone + H2O
-
 Ochrobactrum sp. T63 ATCC 49188 N-acyl-(S)-homoserine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.81 AHL-lactonase
-
 Ochrobactrum sp. T63
3.1.1.81 AidH
-
 Ochrobactrum sp. T63
3.1.1.81 N-acylhomoserine lactonase
-
 Ochrobactrum sp. T63

General Information

EC Number General Information Comment Organism
3.1.1.81 physiological function the enzyme significantly reduces biofilm formation by Pseudomonas fluorescens strain 2P24 and the pathogenicity of Pectobacterium carotovorum indicating that this enzyme is able to effectively quench quorum-sensing-dependent functions in these bacteria by degrading N-acyl-(S)-homoserine lactones Ochrobactrum sp. T63