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Literature summary extracted from

  • Li, M.; Shandilya, S.M.; Carpenter, M.A.; Rathore, A.; Brown, W.L.; Perkins, A.L.; Harki, D.A.; Solberg, J.; Hook, D.J.; Pandey, K.K.; Parniak, M.A.; Johnson, J.R.; Krogan, N.J.; Somasundaran, M.; Ali, A.; Schiffer, C.A.; Harris, R.S.
    First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G (2012), ACS Chem. Biol., 7, 506-517.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.4.B9
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.1 (1R,2S)-(-)-ephedrine
-
Homo sapiens
3.5.4.1 (alpha-D-glucopyranosylthio)gold
-
Homo sapiens
3.5.4.1 (R)-2,10,11-trihydroxy-N-propyl-noraporphine
-
Homo sapiens
3.5.4.1 (R)-2,10,11-trihydroxyaporphine
-
Homo sapiens
3.5.4.1 (R)-apomorphine
-
Homo sapiens
3.5.4.1 (R)-N-allylnorapomorphine
-
Homo sapiens
3.5.4.1 (R)-propylnorapomorphine
-
Homo sapiens
3.5.4.1 (S)-carbidopa
-
Homo sapiens
3.5.4.1 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
-
Homo sapiens
3.5.4.1 3,4-dihydroxyphenylacetic acid
-
Homo sapiens
3.5.4.1 4-chloromercuribenzoic acid
-
Homo sapiens
3.5.4.1 4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
-
Homo sapiens
3.5.4.1 5'-guanidinonaltrindole
-
Homo sapiens
3.5.4.1 6-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
-
Homo sapiens
3.5.4.1 6-hydroxy-DL-DOPA
-
Homo sapiens
3.5.4.1 aurintricarboxylic acid
-
Homo sapiens
3.5.4.1 caffeic acid
-
Homo sapiens
3.5.4.1 cephapirin
-
Homo sapiens
3.5.4.1 dephostatin
-
Homo sapiens
3.5.4.1 dihydrexidine
-
Homo sapiens
3.5.4.1 ebselen
-
Homo sapiens
3.5.4.1 hispidin
-
Homo sapiens
3.5.4.1 hydroquinone
-
Homo sapiens
3.5.4.1 iodoacetamide
-
Homo sapiens
3.5.4.1 methyl 3-hydroxy-DL-tyrosinate
-
Homo sapiens
3.5.4.1 myricetin
-
Homo sapiens
3.5.4.1 N-acetyldopamine
-
Homo sapiens
3.5.4.1 nordihydroguaiaretic acid
-
Homo sapiens
3.5.4.1 p-benzoquinone
-
Homo sapiens
3.5.4.1 piceatannol
-
Homo sapiens
3.5.4.1 PPNDS tetrasodium
-
Homo sapiens
3.5.4.1 SCH202676
-
Homo sapiens
3.5.4.1 SKF-89626
-
Homo sapiens
3.5.4.B9 (12bS)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
-
Homo sapiens
3.5.4.B9 (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol
-
Homo sapiens
3.5.4.B9 (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
Homo sapiens
3.5.4.B9 (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
-
Homo sapiens
3.5.4.B9 (3,4-dihydroxyphenyl)acetic acid
-
Homo sapiens
3.5.4.B9 (5E)-N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine
-
Homo sapiens
3.5.4.B9 (6aR)-6-(prop-2-en-1-yl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
-
Homo sapiens
3.5.4.B9 (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
-
Homo sapiens
3.5.4.B9 (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,10,11-triol
-
Homo sapiens
3.5.4.B9 (6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
-
Homo sapiens
3.5.4.B9 (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-[(pyridin-4-yl)sulfanyl]acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-
Homo sapiens
3.5.4.B9 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
-
Homo sapiens
3.5.4.B9 2-amino-3-(2,4,5-trihydroxyphenyl)propanoic acid
-
Homo sapiens
3.5.4.B9 2-Iodoacetamide
-
Homo sapiens
3.5.4.B9 2-phenyl-1,2-benzoselenazol-3(2H)-one
-
Homo sapiens
3.5.4.B9 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-4H-pyran-4-one
-
Homo sapiens
3.5.4.B9 2-[methyl(nitroso)amino]benzene-1,4-diol
-
Homo sapiens
3.5.4.B9 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-yl)methanediyl]bis(6-hydroxybenzoic acid)
-
Homo sapiens
3.5.4.B9 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
-
Homo sapiens
3.5.4.B9 4,4'-(2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol
-
Homo sapiens
3.5.4.B9 4-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-yl)benzene-1,2-diol
-
Homo sapiens
3.5.4.B9 4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
-
Homo sapiens
3.5.4.B9 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
-
Homo sapiens
3.5.4.B9 4-[methyl(nitroso)amino]benzene-1,2-diol
-
Homo sapiens
3.5.4.B9 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
-
Homo sapiens
3.5.4.B9 aurothio-beta-D-glucose
-
Homo sapiens
3.5.4.B9 benzene-1,4-diol
-
Homo sapiens
3.5.4.B9 cephapirin
-
Homo sapiens
3.5.4.B9 cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
3.5.4.B9 methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate
-
Homo sapiens
3.5.4.B9 N-[(4bS,8R,8aS)-7-(cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazol-11-yl]guanidine
-
Homo sapiens
3.5.4.B9 N-[2-(3,4-dihydroxyphenyl)ethyl]acetamide
-
Homo sapiens
3.5.4.B9 p-chloromercuribenzoate
-
Homo sapiens
3.5.4.B9 tetrasodium 3-[(E)-[4-formyl-5,6-dihydroxy-3-[(phosphonatoperoxy)methyl]pyridin-2-yl]diazenyl]-7-nitronaphthalene-1,5-disulfonate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.B9 cytosine in single-stranded viral DNA + H2O Homo sapiens
-
uracil in single-stranded viral DNA + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.1 Homo sapiens
-
-
-
3.5.4.B9 Homo sapiens Q9HC16
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.B9
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.1 HEK-293 cell
-
Homo sapiens
-
3.5.4.B9 HEK-293T cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.1 5-fluorocytosine + H2O
-
Homo sapiens 5-fluorouracil + NH3
-
?
3.5.4.B9 cytosine in single-stranded viral DNA + H2O
-
Homo sapiens uracil in single-stranded viral DNA + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.1 APOBEC3G
-
Homo sapiens
3.5.4.B9 A3G
-
Homo sapiens
3.5.4.B9 APOBEC3G
-
Homo sapiens
3.5.4.B9 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.1 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.1 7.4
-
assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.4.1 0.00013
-
pH 7.4, 37°C Homo sapiens 4-chloromercuribenzoic acid
3.5.4.1 0.00017
-
pH 7.4, 37°C Homo sapiens p-benzoquinone
3.5.4.1 0.00036
-
pH 7.4, 37°C Homo sapiens (alpha-D-glucopyranosylthio)gold
3.5.4.1 0.00043
-
pH 7.4, 37°C Homo sapiens dephostatin
3.5.4.1 0.00045
-
pH 7.4, 37°C Homo sapiens N-acetyldopamine
3.5.4.1 0.00049
-
pH 7.4, 37°C Homo sapiens aurintricarboxylic acid
3.5.4.1 0.00059
-
pH 7.4, 37°C Homo sapiens dihydrexidine
3.5.4.1 0.0007
-
pH 7.4, 37°C Homo sapiens 6-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
3.5.4.1 0.0013
-
pH 7.4, 37°C Homo sapiens (R)-apomorphine
3.5.4.1 0.0013
-
pH 7.4, 37°C Homo sapiens SKF-89626
3.5.4.1 0.0013
-
pH 7.4, 37°C Homo sapiens (1R,2S)-(-)-ephedrine
3.5.4.1 0.0017
-
pH 7.4, 37°C Homo sapiens (R)-2,10,11-trihydroxyaporphine
3.5.4.1 0.0018
-
pH 7.4, 37°C Homo sapiens piceatannol
3.5.4.1 0.002
-
pH 7.4, 37°C Homo sapiens hispidin
3.5.4.1 0.0026
-
pH 7.4, 37°C Homo sapiens hydroquinone
3.5.4.1 0.0028
-
pH 7.4, 37°C Homo sapiens ebselen
3.5.4.1 0.0029
-
pH 7.4, 37°C Homo sapiens (R)-N-allylnorapomorphine
3.5.4.1 0.003
-
pH 7.4, 37°C Homo sapiens iodoacetamide
3.5.4.1 0.0034
-
pH 7.4, 37°C Homo sapiens myricetin
3.5.4.1 0.0035
-
pH 7.4, 37°C Homo sapiens 4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
3.5.4.1 0.004
-
pH 7.4, 37°C Homo sapiens 6-hydroxy-DL-DOPA
3.5.4.1 0.0053
-
pH 7.4, 37°C Homo sapiens (S)-carbidopa
3.5.4.1 0.0056
-
pH 7.4, 37°C Homo sapiens PPNDS tetrasodium
3.5.4.1 0.006
-
pH 7.4, 37°C Homo sapiens (R)-propylnorapomorphine
3.5.4.1 0.0064
-
pH 7.4, 37°C Homo sapiens 5'-guanidinonaltrindole
3.5.4.1 0.0075
-
pH 7.4, 37°C Homo sapiens cephapirin
3.5.4.1 0.0088
-
pH 7.4, 37°C Homo sapiens nordihydroguaiaretic acid
3.5.4.1 0.0091
-
pH 7.4, 37°C Homo sapiens dephostatin
3.5.4.1 0.013
-
pH 7.4, 37°C Homo sapiens methyl 3-hydroxy-DL-tyrosinate
3.5.4.1 0.013
-
pH 7.4, 37°C Homo sapiens (R)-2,10,11-trihydroxy-N-propyl-noraporphine
3.5.4.1 0.019
-
pH 7.4, 37°C Homo sapiens 3,4-dihydroxyphenylacetic acid
3.5.4.1 0.027
-
pH 7.4, 37°C Homo sapiens 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
3.5.4.1 0.029
-
pH 7.4, 37°C Homo sapiens SCH202676
3.5.4.1 0.085
-
pH 7.4, 37°C Homo sapiens caffeic acid
3.5.4.B9 0.00013
-
at pH 7.8 and 37°C Homo sapiens p-chloromercuribenzoate
3.5.4.B9 0.00017
-
at pH 7.8 and 37°C Homo sapiens cyclohexa-2,5-diene-1,4-dione
3.5.4.B9 0.00036
-
at pH 7.8 and 37°C Homo sapiens aurothio-beta-D-glucose
3.5.4.B9 0.00043
-
at pH 7.8 and 37°C Homo sapiens 2-[methyl(nitroso)amino]benzene-1,4-diol
3.5.4.B9 0.00045
-
at pH 7.8 and 37°C Homo sapiens N-[2-(3,4-dihydroxyphenyl)ethyl]acetamide
3.5.4.B9 0.00049
-
at pH 7.8 and 37°C Homo sapiens 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-yl)methanediyl]bis(6-hydroxybenzoic acid)
3.5.4.B9 0.00059
-
at pH 7.8 and 37°C Homo sapiens (12bS)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
3.5.4.B9 0.0007
-
at pH 7.8 and 37°C Homo sapiens 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
3.5.4.B9 0.0013
-
at pH 7.8 and 37°C Homo sapiens (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol
3.5.4.B9 0.0013
-
at pH 7.8 and 37°C Homo sapiens (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
3.5.4.B9 0.0013
-
at pH 7.8 and 37°C Homo sapiens 4-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-yl)benzene-1,2-diol
3.5.4.B9 0.0017
-
at pH 7.8 and 37°C Homo sapiens (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,10,11-triol
3.5.4.B9 0.0018
-
at pH 7.8 and 37°C Homo sapiens 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
3.5.4.B9 0.002
-
at pH 7.8 and 37°C Homo sapiens 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-4H-pyran-4-one
3.5.4.B9 0.0026
-
at pH 7.8 and 37°C Homo sapiens benzene-1,4-diol
3.5.4.B9 0.0028
-
at pH 7.8 and 37°C Homo sapiens 2-phenyl-1,2-benzoselenazol-3(2H)-one
3.5.4.B9 0.0029
-
at pH 7.8 and 37°C Homo sapiens (6aR)-6-(prop-2-en-1-yl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
3.5.4.B9 0.003
-
at pH 7.8 and 37°C Homo sapiens 2-Iodoacetamide
3.5.4.B9 0.0034
-
at pH 7.8 and 37°C Homo sapiens 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
3.5.4.B9 0.0035
-
at pH 7.8 and 37°C Homo sapiens 4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
3.5.4.B9 0.004
-
at pH 7.8 and 37°C Homo sapiens 2-amino-3-(2,4,5-trihydroxyphenyl)propanoic acid
3.5.4.B9 0.0053
-
at pH 7.8 and 37°C Homo sapiens (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
3.5.4.B9 0.0056
-
at pH 7.8 and 37°C Homo sapiens tetrasodium 3-[(E)-[4-formyl-5,6-dihydroxy-3-[(phosphonatoperoxy)methyl]pyridin-2-yl]diazenyl]-7-nitronaphthalene-1,5-disulfonate
3.5.4.B9 0.0064
-
at pH 7.8 and 37°C Homo sapiens (6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
3.5.4.B9 0.0064
-
at pH 7.8 and 37°C Homo sapiens N-[(4bS,8R,8aS)-7-(cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazol-11-yl]guanidine
3.5.4.B9 0.0075
-
at pH 7.8 and 37°C Homo sapiens (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-[(pyridin-4-yl)sulfanyl]acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
3.5.4.B9 0.0088
-
at pH 7.8 and 37°C Homo sapiens 4,4'-(2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol
3.5.4.B9 0.0091
-
at pH 7.8 and 37°C Homo sapiens 4-[methyl(nitroso)amino]benzene-1,2-diol
3.5.4.B9 0.013
-
at pH 7.8 and 37°C Homo sapiens cephapirin
3.5.4.B9 0.013
-
at pH 7.8 and 37°C Homo sapiens methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate
3.5.4.B9 0.019
-
at pH 7.8 and 37°C Homo sapiens (3,4-dihydroxyphenyl)acetic acid
3.5.4.B9 0.027
-
at pH 7.8 and 37°C Homo sapiens 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
3.5.4.B9 0.029
-
at pH 7.8 and 37°C Homo sapiens (5E)-N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine
3.5.4.B9 0.085
-
at pH 7.8 and 37°C Homo sapiens (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid