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Literature summary extracted from

  • Liu, L.; Ma, H.; Yang, N.; Tang, Y.; Guo, J.; Tao, W.; Duan, J.
    A series of natural flavonoids as thrombin inhibitors: structure-activity relationships (2010), Thromb. Res., 126, e365-e378.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.5 acacetin
-
 Bos taurus
3.4.21.5 amentoflavone slight inhibition Bos taurus
3.4.21.5 apigenin
-
 Bos taurus
3.4.21.5 baicalein
-
 Bos taurus
3.4.21.5 Baicalin slight inhibition Bos taurus
3.4.21.5 dihydromyricetin slight inhibition Bos taurus
3.4.21.5 epicatechin slight inhibition Bos taurus
3.4.21.5 galangin slight inhibition Bos taurus
3.4.21.5 hesperetin slight inhibition Bos taurus
3.4.21.5 hesperidin slight inhibition Bos taurus
3.4.21.5 hinokiflavone
-
 Bos taurus
3.4.21.5 hyperin slight inhibition Bos taurus
3.4.21.5 isohamnetin 3-O-nehesperridin slight inhibition Bos taurus
3.4.21.5 isorhamnetin
-
 Bos taurus
3.4.21.5 isorhamnetin 3-O-(6-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside slight inhibition Bos taurus
3.4.21.5 kaempferol
-
 Bos taurus
3.4.21.5 kaempferol 3-O-(2'',4''-di-(E)-p-coumaroyl)-rhamnoside
-
 Bos taurus
3.4.21.5 kaempferol 3-O-(2''-p-coumaroyl)-rhamnoside
-
 Bos taurus
3.4.21.5 kaempferol 3-O-(2-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside slight inhibition Bos taurus
3.4.21.5 kaempferol 3-O-beta-D-glucoside slight inhibition Bos taurus
3.4.21.5 luteolin
-
 Bos taurus
3.4.21.5 additional information a series of natural flavonoids as thrombin inhibitors, structure-activity relationships, molecular docking, overview Bos taurus
3.4.21.5 myricetin
-
 Bos taurus
3.4.21.5 Myricitrin slight inhibition Bos taurus
3.4.21.5 naringenin slight inhibition Bos taurus
3.4.21.5 naringin slight inhibition Bos taurus
3.4.21.5 puerarin slight inhibition Bos taurus
3.4.21.5 quercetin
-
 Bos taurus
3.4.21.5 quercetin 3-O-rhamnose(1-2)glucose(6-1)rhamnose slight inhibition Bos taurus
3.4.21.5 rutin slight inhibition Bos taurus
3.4.21.5 typhaneoside slight inhibition Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.5 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.5 commercial preparation
-
 Bos taurus
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.5 0.006
-
 pH and temperature not specified in the publication Bos taurus myricetin
3.4.21.5 0.035
-
 pH and temperature not specified in the publication Bos taurus quercetin
3.4.21.5 0.052
-
 pH and temperature not specified in the publication Bos taurus luteolin
3.4.21.5 0.052
-
 pH and temperature not specified in the publication Bos taurus kaempferol 3-O-(2'',4''-di-(E)-p-coumaroyl)-rhamnoside
3.4.21.5 0.06
-
 pH and temperature not specified in the publication Bos taurus baicalein
3.4.21.5 0.071
-
 pH and temperature not specified in the publication Bos taurus hinokiflavone
3.4.21.5 0.083
-
 pH and temperature not specified in the publication Bos taurus kaempferol 3-O-(2''-p-coumaroyl)-rhamnoside
3.4.21.5 0.109
-
 pH and temperature not specified in the publication Bos taurus kaempferol
3.4.21.5 0.14
-
 pH and temperature not specified in the publication Bos taurus acacetin
3.4.21.5 0.18
-
 pH and temperature not specified in the publication Bos taurus apigenin
3.4.21.5 0.246
-
 pH and temperature not specified in the publication Bos taurus isorhamnetin