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Literature summary extracted from

  • Oliveira, A.K.; Paes Leme, A.F.; Asega, A.F.; Camargo, A.C.; Fox, J.W.; Serrano, S.M.
    New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases (2010), Thromb. Haemost., 104, 485-497.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.4.24.49 N-deglycosylation causes loss of structural stability of bothropasin Bothrops jararaca

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.49 Bothrops jararaca
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.49 glycoprotein N-deglycosylation causes loss of structural stability of bothropasin Bothrops jararaca

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.49 collagen I + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.49 Collagen IV + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.49 collagen VI + H2O from human placenta Bothrops jararaca ?
-
 ?
3.4.24.49 Fibrinogen + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.49 fibrinonectin + H2O from human plasma Bothrops jararaca ?
-
 ?
3.4.24.49 Matrigel + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.49 additional information bothropasin degradation profiles of fibrinogen, fibronectin, vitronectin, von Willebrand factor, collagens IV and VI, laminin and Matrigel in comparison to the other three snake venom metalloproteinases of Bothrops jararaca, binding to plasma and extracellular matrix proteins, overview. Collagen I is degraded only by bothropasin Bothrops jararaca ?
-
 ?
3.4.24.49 Vitronectin + H2O from human plasma Bothrops jararaca ?
-
 ?
3.4.24.49 von Willebrand factor + H2O
-
 Bothrops jararaca ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.49 More bothropasin is aof P-III class and has a minor carbohydrate moiety and disintegrin-like/cysteine-rich domains Bothrops jararaca

Synonyms

EC Number Synonyms Comment Organism
3.4.24.49 Bothrops jararaca snake venom metalloproteinase
-
 Bothrops jararaca

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.49 37
-
 assay at Bothrops jararaca

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.49 7.5
-
 assay at Bothrops jararaca

General Information

EC Number General Information Comment Organism
3.4.24.49 additional information role of the non-catalytic domains of snake venom metalloproteinases, interaction of four snake venom metalloproteinases of different domain compositions and glycosylation levels, from Bothrops jararaca venom, with plasma and extracellular matrix proteins, overview Bothrops jararaca
3.4.24.49 physiological function haemorrhagic effect of bothropasin on mouse skin, overview Bothrops jararaca