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Literature summary extracted from
- Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex (2010), Proc. Natl. Acad. Sci. USA, 107, 645-650.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.22 | Factor VIIIa | - |
Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.22 | expressed in Escherichia coli BL21 Star (DE3) cells | Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.21.22 | hanging drop vapor diffusion method, using 0.25 M ammonium acetate, 19.5% (w/v) PEG 3350 | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.22 | antithrombin | - |
Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.22 | Ca2+ | factor IXa contains a high-affinity Ca2+-binding site | Homo sapiens |  |
| 3.4.21.22 | additional information | factor IXa is not a Na+-binding protease | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.22 | Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.22 | Homo sapiens | P00740 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.22 | heparin Sepharose column chromatography and Q Sepharose column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.22 | Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.22 | factor IXa | - |
Homo sapiens |
| 3.4.21.22 | FIXa | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.22 | malfunction | factor IXa deficiency results in hemophilia | Homo sapiens |
| 3.4.21.22 | physiological function | factor IXa is a critical enzyme for the formation of stable blood clots | Homo sapiens |
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Release 2023.1 (January 2023)
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