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Literature summary extracted from

  • Collu, G.; Garcia, A.; Van der Heijden, R.; Verpoorte, R.
    Activity of the cytochrome P450 enzyme geraniol 10-hydroxylase and alkaloid production in plant cell cultures (2002), Plant Sci., 162, 165-172.
No PubMed abstract available

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.83 membrane
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Catharanthus roseus 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
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(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.83 Catharanthus roseus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.83 58CrPM cell
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Catharanthus roseus
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1.14.14.83 cell culture G10H activity is correlated to the ability of the cells to accumulate terpenoid indole alkaloids. Alkaloid induction medium induces the enzyme, overview Catharanthus roseus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
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Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.83 G10H
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Catharanthus roseus
1.14.14.83 geraniol 10-hydroxylase
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Catharanthus roseus

Expression

EC Number Organism Comment Expression
1.14.14.83 Catharanthus roseus alkaloid induction medium induces the enzyme, overview up

General Information

EC Number General Information Comment Organism
1.14.14.83 evolution the enzyme belongs to the cytochrome-P450 monooxygenase family Catharanthus roseus
1.14.14.83 metabolism the enzyme is involved in the 2-C-methyl-D-erythritol-4-phosphate/terpenoid metabolic pathway part of the iridoid pathway, overview. Induction of G10H is a requirement, but not the only, necessary to produce other terpenoid indole alkaloids than strictosidine Catharanthus roseus