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Literature summary extracted from

  • Burlat, V.; Oudin, A.; Courtois, M.; Rideau, M.; St-Pierre, B.
    Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derive (2004), Plant J., 38, 131-141.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
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 (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.83 Catharanthus roseus Q8VWZ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.83 aerial tissue young Catharanthus roseus
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1.14.14.83 leaf
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 Catharanthus roseus
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1.14.14.83 additional information the enzyme is expressed in almost all tissues, except for flower and fruit, in situ RNA tissue hybridization, overview. Tissue localization of the enzyme and related primary metabolic pathways, overview Catharanthus roseus
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1.14.14.83 phloem parenchym Catharanthus roseus
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1.14.14.83 phloem parenchyma cell
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 Catharanthus roseus
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1.14.14.83 stem
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.83 CYP76B6
-
 Catharanthus roseus
1.14.14.83 G10H
-
 Catharanthus roseus
1.14.14.83 geraniol 10-hydroxylase
-
 Catharanthus roseus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.83 cytochrome P450
-
 Catharanthus roseus

General Information

EC Number General Information Comment Organism
1.14.14.83 evolution the enzyme belongs to the cytochrome-P450 monooxygenase family Catharanthus roseus
1.14.14.83 metabolism the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview Catharanthus roseus
1.14.14.83 physiological function the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview Catharanthus roseus