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Literature summary extracted from

  • Zhang, Y.; Nowak, G.; Reed, D.W.; Covello, P.S.
    The production of artemisinin precursors in tobacco (2011), Plant Biotechnol. J., 9, 445-454.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.114 synthesis heterologous expression of Artemisia annua amorphadiene synthase and CYP71AV1 in tobacco lead to the accumulation of amorphadiene and artemisinic alcohol, but not artemisinic acid. Additional expression of artemisinic aldehyde DELTA11(13) double-bond reductase DBR2 with or without aldehyde dehydrogenase 1 leads to the additional accumulation dihydroartemisinic alcohol. Results and suggest that amorphane sesquiterpenoid aldehydes are formed, but conditions in the transgenic tobacco cells favour reduction to alcohols rather than oxidation to acids Artemisia annua

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.92 additional information heterologous expression of Artemisia annua amorphadiene synthase and CYP71AV1, the cytochrome P450 responsible for oxidation of amorphadiene, in tobacco lead to the accumulation of amorphadiene and artemisinic alcohol, but not artemisinic acid, in leaf. Additional expression of artemisinic aldehyde DELTA11(13) double-bond reductase with or without aldehyde dehydrogenase 1 leads to the additional accumulation dihydroartemisinic alcohol Artemisia annua

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.92 Artemisia annua C5H429
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1.14.14.114 Artemisia annua
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Synonyms

EC Number Synonyms Comment Organism
1.3.1.92 artemisinic aldehyde DELTA11(13) double-bond reductase
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 Artemisia annua