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Literature summary extracted from
- HTRA proteases: regulated proteolysis in protein quality control (2011), Nat. Rev. Mol. Cell Biol., 12, 152-162.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.107 | cell envelope | - |
Escherichia coli | 30313 | - |
| 3.4.21.107 | chloroplast | - |
Arabidopsis thaliana | 9507 | - |
| 3.4.21.107 | chloroplast stroma | isoform DEG2 only | Arabidopsis thaliana | 9570 | - |
| 3.4.21.107 | cytoplasmic membrane | isoform HTRA1 | Homo sapiens | - |
- |
| 3.4.21.107 | mitochondrion | isoform HTRA2 | Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | biglycan + H2O | Homo sapiens | substrate of isoforms HTRA1 and HTRA3 | ? | - |
? |  |
| 3.4.21.107 | bone morphogenetic protein + H2O | Homo sapiens | substrate of isoform HTRA1 | ? | - |
? | |
| 3.4.21.107 | decorin + H2O | Homo sapiens | substrate of isoforms HTRA1 and HTRA3 | ? | - |
? | |
| 3.4.21.107 | E-cadherin + H2O | Helicobacter pylori | - |
? | - |
? | |
| 3.4.21.107 | Fibronectin + H2O | Homo sapiens | substrate of isoform HTRA1 | ? | - |
? | |
| 3.4.21.107 | HCLS1-associated X1 + H2O | Homo sapiens | substrate of isoform HTRA2 | ? | - |
? | |
| 3.4.21.107 | insulin growth factor-binding protein 5 + H2O | Homo sapiens | substrate of isoform HTRA1 | ? | - |
? | |
| 3.4.21.107 | additional information | Homo sapiens | HTRA1 interacts with presenilin 1 to cleave one product of gamma-secretase | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D1 + H2O | Escherichia coli | substrate of isoform DEG1 | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D1 + H2O | Arabidopsis thaliana | substrate of isoform DEG1 | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D2 + H2O | Escherichia coli | substrate of isoforms DEG1, DEG5, DEG7 and DEG8 | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D2 + H2O | Arabidopsis thaliana | substrate of isoforms DEG1, DEG5, DEG7 and DEG8 | ? | - |
? | |
| 3.4.21.107 | transforming growth factor-beta + H2O | Homo sapiens | substrate of isoform HTRA1 | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Arabidopsis thaliana | - |
- |
- |
| 3.4.21.107 | Escherichia coli | - |
- |
- |
| 3.4.21.107 | Helicobacter pylori | - |
- |
- |
| 3.4.21.107 | Homo sapiens | - |
- |
- |
| 3.4.21.107 | Streptococcus mutans | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | biglycan + H2O | substrate of isoforms HTRA1 and HTRA3 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | bone morphogenetic protein + H2O | substrate of isoform HTRA1 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | decorin + H2O | substrate of isoforms HTRA1 and HTRA3 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | E-cadherin + H2O | - |
Helicobacter pylori | ? | - |
? | |
| 3.4.21.107 | Fibronectin + H2O | substrate of isoform HTRA1 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | HCLS1-associated X1 + H2O | substrate of isoform HTRA2 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | insulin growth factor-binding protein 5 + H2O | substrate of isoform HTRA1 | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | additional information | HTRA1 interacts with presenilin 1 to cleave one product of gamma-secretase | Homo sapiens | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D1 + H2O | substrate of isoform DEG1 | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D1 + H2O | substrate of isoform DEG1 | Arabidopsis thaliana | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D2 + H2O | substrate of isoforms DEG1, DEG5, DEG7 and DEG8 | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | reaction centre protein D2 + H2O | substrate of isoforms DEG1, DEG5, DEG7 and DEG8 | Arabidopsis thaliana | ? | - |
? | |
| 3.4.21.107 | transforming growth factor-beta + H2O | substrate of isoform HTRA1 | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | oligomer | DegP protease chaperone system is regulated by oligomer conversion from the resting hexamer into the catalytically active 12mer and 24mer that capture and digest misfolded proteins | Escherichia coli |
| 3.4.21.107 | trimer | - |
Homo sapiens |
| 3.4.21.107 | trimer | - |
Arabidopsis thaliana |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | Deg1 | isoform | Arabidopsis thaliana |
| 3.4.21.107 | DEG2 | isoform | Arabidopsis thaliana |
| 3.4.21.107 | DEG5 | isoform | Arabidopsis thaliana |
| 3.4.21.107 | DEG7 | isoform | Arabidopsis thaliana |
| 3.4.21.107 | DEG8 | isoform | Arabidopsis thaliana |
| 3.4.21.107 | DegP | - |
Escherichia coli |
| 3.4.21.107 | high temperature requirement A protease | - |
Escherichia coli |
| 3.4.21.107 | high temperature requirement A protease | - |
Homo sapiens |
| 3.4.21.107 | high temperature requirement A protease | - |
Arabidopsis thaliana |
| 3.4.21.107 | high temperature requirement A protease | - |
Helicobacter pylori |
| 3.4.21.107 | high temperature requirement A protease | - |
Streptococcus mutans |
| 3.4.21.107 | HtrA | - |
Escherichia coli |
| 3.4.21.107 | HtrA | - |
Arabidopsis thaliana |
| 3.4.21.107 | HtrA | - |
Streptococcus mutans |
| 3.4.21.107 | HtrA1 | isoform | Homo sapiens |
| 3.4.21.107 | HtrA1 | isoform | Helicobacter pylori |
| 3.4.21.107 | HtrA2 | isoform | Homo sapiens |
| 3.4.21.107 | HtrA3 | isoform | Homo sapiens |
| 3.4.21.107 | HTRA4 | isoform | Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.21.107 | Homo sapiens | the activity of isoform HTRA2 is stimulated by phosphorylation downstream of PTEN-induced putative kinase 1 and the p38 stress kinase pathway | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | malfunction | the loss of HTRA activity is correlated with severe diseases, including arthritis, cancer, familial ischemic cerebral smallvessel disease and age-related macular degeneration, as well as Parkinsons disease and Alzheimers disease | Homo sapiens |
| 3.4.21.107 | physiological function | HtrA acts as chaperone and protease | Helicobacter pylori |
| 3.4.21.107 | physiological function | HtrA acts as chaperone and protease. DEG1 interacts with the reaction centre protein D2 and assists in the assembly of photosystem II | Escherichia coli |
| 3.4.21.107 | physiological function | HtrA acts as chaperone and protease. DEG1 interacts with the reaction centre protein D2 and assists in the assembly of photosystem II | Arabidopsis thaliana |
| 3.4.21.107 | physiological function | HtrA is important for the biogenesis of extracellular proteins and thus for biofilm formation | Streptococcus mutans |
| 3.4.21.107 | physiological function | isoform HTRA1 regulates cell proliferation by sequestering or proteolysing transforming growth factor-beta and bone morphogenetic protein, proteins of the transforming growth factor family, and IGF-binding protein 5 in the extracellular matrix. Isoform HTRA2 affects quality control in the intermembrane space of mitochondria. HTRA1 and HTRA2 are implicated in tumor suppression and in the control of proliferation, migration and neurodegeneration. Isoform HTRA3 is implicated in pregnancy, and endometrial and ovarian cancers55 | Homo sapiens |
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Release 2023.1 (January 2023)
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