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Literature summary extracted from

  • Georgiadou, D.; Hearn, A.; Evnouchidou, I.; Chroni, A.; Leondiadis, L.; York, I.A.; Rock, K.L.; Stratikos, E.
    Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1 (2010), J. Immunol., 185, 1584-1592.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.1 a myc-His-tagged soluble version starting at amino acid position 155 (lacking the putative transmembrane region) expressed in 293F cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.1 immobilized metal ion affinity chromatography (Ni2+), anion-exchange chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.1 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.11.1 additional information
-
 233000 mol L-leucine-7-amido-4-methyl coumarin/mol enzyme x min Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.1 L-leucine-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-leucine + 7-amino-4-methylcoumarin
-
 ?
3.4.11.1 Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O
-
 Homo sapiens ? + Ile-Asn-Phe-Glu-Lys-Leu
-
 ?
3.4.11.1 Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O
-
 Homo sapiens ? + Ile-Ile-Asn-Phe-Glu-Lys-Leu
-
 ?
3.4.11.1 Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O trimming of further model epitope precursors to antigenic peptides are also tested Homo sapiens L-leucine + Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.1 Placental leucine aminopeptidase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.1 7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.11.1 6 8 almost 70% activity at pH 6.0, 50% activity at pH 8.0 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.11.1 physiological function enzymatic properties to participate in generating or destroying MHC class I-presented peptides Homo sapiens