EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.73 | 2-phenethyl-SO2-D-Ser-Ala-Arg-al | is an irreversible urokinase inhibitor, and an alkylating agent forming a covalent adduct with an active site of the enzyme | Homo sapiens | |
3.4.21.73 | D-Ser-Ala-Arg-NH-(CH2)5-NH2 | competitive inhibition | Homo sapiens | |
3.4.21.73 | D-Ser-Ala-Arg-NH-(CH2)7-NH2 | - |
Homo sapiens | |
3.4.21.73 | D-Ser-Ala-Arg-NH-(CH2)8-NH2 | - |
Homo sapiens | |
3.4.21.73 | D-Ser-Ala-Arg-NH-(CH2)9-NH2 | - |
Homo sapiens | |
3.4.21.73 | i-Boc-D-Ser-Ala-Arg-al | is an alkylating agent, and irreversibly inhibits urokinase by forming a covalent adduct with an active site of the enzyme | Homo sapiens | |
3.4.21.73 | additional information | synthesis and inhibitory potencies of d-Ser-Ala-Arg-NH-X peptides, overview. All compounds with a hydroxyl residue of an amide group do not inhibit urokinase, no inhibition by D-Ser-Ala-Arg-NH | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | plasminogen + H2O | Homo sapiens | - |
plasmin + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.73 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.73 | commercial preparation | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.73 | Urokinase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.73 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.73 | 8.8 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.73 | 0.0063 | - |
D-Ser-Ala-Arg-NH-(CH2)5-NH2 | pH 8.8, 37°C | Homo sapiens |