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Literature summary extracted from

  • Markowska, A.; Bruzgo, I.; Midura-Nowaczek, K.
    Synthesis and activity of amides of tripeptides as potential urokinase inhibitors (2010), J. Enzyme Inhib. Med. Chem., 25, 139-142.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 2-phenethyl-SO2-D-Ser-Ala-Arg-al is an irreversible urokinase inhibitor, and an alkylating agent forming a covalent adduct with an active site of the enzyme Homo sapiens
3.4.21.73 D-Ser-Ala-Arg-NH-(CH2)5-NH2 competitive inhibition Homo sapiens
3.4.21.73 D-Ser-Ala-Arg-NH-(CH2)7-NH2
-
Homo sapiens
3.4.21.73 D-Ser-Ala-Arg-NH-(CH2)8-NH2
-
Homo sapiens
3.4.21.73 D-Ser-Ala-Arg-NH-(CH2)9-NH2
-
Homo sapiens
3.4.21.73 i-Boc-D-Ser-Ala-Arg-al is an alkylating agent, and irreversibly inhibits urokinase by forming a covalent adduct with an active site of the enzyme Homo sapiens
3.4.21.73 additional information synthesis and inhibitory potencies of d-Ser-Ala-Arg-NH-X peptides, overview. All compounds with a hydroxyl residue of an amide group do not inhibit urokinase, no inhibition by D-Ser-Ala-Arg-NH Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
plasmin + ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 Urokinase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.73 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.73 8.8
-
assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.73 0.0063
-
D-Ser-Ala-Arg-NH-(CH2)5-NH2 pH 8.8, 37°C Homo sapiens