EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.37 | GW311616A | - |
Homo sapiens | |
3.4.21.37 | additional information | neutrophil elastase is not inhibited by 4-aminobenzoic acid hydrazide | Homo sapiens | |
3.4.21.37 | serum leukocyte protease inhibitor | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.37 | nucleus | active form | Homo sapiens | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.37 | histone H1 + H2O | Homo sapiens | - |
? | - |
? | |
3.4.21.37 | histone H4 + H2O | Homo sapiens | - |
? | - |
? | |
3.4.21.37 | additional information | Homo sapiens | histone H3 is not degraded by neutrophil elastase | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.37 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.37 | HeLa cell | - |
Homo sapiens | - |
3.4.21.37 | HL-60 cell | - |
Homo sapiens | - |
3.4.21.37 | neutrophil | - |
Homo sapiens | - |
3.4.21.37 | peripheral blood mononuclear cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.37 | histone H1 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.37 | histone H4 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.37 | additional information | histone H3 is not degraded by neutrophil elastase | Homo sapiens | ? | - |
? | |
3.4.21.37 | additional information | high concentrations of neutrophil elastase inhibit nuclear decondensation. This autoinhibition can be caused by neutrophil elastase autodegradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.37 | neutrophil elastase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.37 | malfunction | neutrophil elastase knockout mice do not form neutrophil extracellular traps in a pulmonary model of Klebsiella pneumoniae infection | Homo sapiens |
3.4.21.37 | physiological function | upon activation, neutrophil elastase escapes from azurophilic granules and translocates to the nucleus, where it partially degrades specific histones, promoting chromatin decondensation. Myeloperoxidase synergizes with neutrophil elastase in driving chromatin decondensation. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps | Homo sapiens |