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Literature summary extracted from

  • Papayannopoulos, V.; Metzler, K.D.; Hakkim, A.; Zychlinsky, A.
    Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010), J. Cell Biol., 191, 677-691.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 GW311616A
-
 Homo sapiens
3.4.21.37 additional information neutrophil elastase is not inhibited by 4-aminobenzoic acid hydrazide Homo sapiens
3.4.21.37 serum leukocyte protease inhibitor
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.37 nucleus active form Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 histone H1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.37 histone H4 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.37 additional information Homo sapiens histone H3 is not degraded by neutrophil elastase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 HeLa cell
-
 Homo sapiens
-
3.4.21.37 HL-60 cell
-
 Homo sapiens
-
3.4.21.37 neutrophil
-
 Homo sapiens
-
3.4.21.37 peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 histone H1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 histone H4 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 additional information histone H3 is not degraded by neutrophil elastase Homo sapiens ?
-
 ?
3.4.21.37 additional information high concentrations of neutrophil elastase inhibit nuclear decondensation. This autoinhibition can be caused by neutrophil elastase autodegradation Homo sapiens ?
-
 ?
3.4.21.37 N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 neutrophil elastase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.37 malfunction neutrophil elastase knockout mice do not form neutrophil extracellular traps in a pulmonary model of Klebsiella pneumoniae infection Homo sapiens
3.4.21.37 physiological function upon activation, neutrophil elastase escapes from azurophilic granules and translocates to the nucleus, where it partially degrades specific histones, promoting chromatin decondensation. Myeloperoxidase synergizes with neutrophil elastase in driving chromatin decondensation. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps Homo sapiens