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Literature summary extracted from

  • Majumder, R.; Liang, X.; Quinn-Allen, M.A.; Kane, W.H.; Lentz, B.R.
    Modulation of prothrombinase assembly and activity by phosphatidylethanolamine (2011), J. Biol. Chem., 286, 35535-35542.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.6 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine activates prothrombinase activity after enzyme binding to membranes, binding to model membranes, binding of prothrombinase via factor Va, overview. 1,2-diphytanoyl-sn-glycero-3-phosphocholine deminishes activation by 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine Bos taurus
3.4.21.6 1,2-dioleoyl-sn-glycero-3-phosphoserine
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 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Bos taurus
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-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 prothrombinase
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 Bos taurus

General Information

EC Number General Information Comment Organism
3.4.21.6 metabolism constituents of platelet membranes regulate the activity of the prothrombinase complex. Membranes containing phosphatidylcholine and phosphatidylethanolamine bind factor Va with high affinity in the absence of phosphatidylserine, specific protein-PE interactions appear to contribute to the effects of phosphatidylethanolamine Bos taurus