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Literature summary extracted from

  • Goto, Y.; Ogawa, K.; Hattori, A.; Tsujimoto, M.
    Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (2011), J. Biol. Chem., 286, 21906-21914.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.22 expressed in Sf9 insect cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.11.22 E354Q inactive, Zn2+ binding site disrupted Mus musculus
3.4.11.22 Q181E different substrate specificity, cleaves basic amino acid residues preferentially Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.22 amastatin
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.22 endoplasmic reticulum
-
 Mus musculus 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.22 105000
-
 x * 105000, also a 114000 form of the glycoprotein, SDS-PAGE, Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.22 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.22 glycoprotein
-
 Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.22 from culture medium, hydroxyapatite chromatography, immobilized metal ion affinity chromatography (Co2+) Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.22 RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.22 L-leucine-4-methylcoumaryl-7-amide + H2O
-
 Mus musculus L-leucine + 7-amino-4-methylcoumarin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.11.22 ? x * 105000, also a 114000 form of the glycoprotein, SDS-PAGE, Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.11.22 endoplasmic reticulum aminopeptidase 1
-
 Mus musculus
3.4.11.22 ERAP1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.11.22 physiological function secreted from RAW-264.7 cells after costimulation with lipopolysaccharide and interferon-gamma Mus musculus