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Literature summary extracted from

  • Cheng, J.B.; Motola, D.L.; Mangelsdorf, D.J.; Russell, D.W.
    De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase (2003), J. Biol. Chem., 278, 38084-38093.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.24 expression in HEK 293 cell Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.24 microsome
-
 Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.24 Mus musculus Q6VVW9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.24 liver CYP2R1 mRNA is abundant in the liver and testis Mus musculus
-
1.14.14.24 testis CYP2R1 mRNA is abundant in the liver and testis Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.24 vitamin D3 + O2 + NADPH + H+
-
 Mus musculus 25-hydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.24 CYP2R1
-
 Mus musculus
1.14.14.24 cytochrome P450 2R1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.14.24 physiological function expression of CYP2R1 in HEK 293 cells leads to the transcriptional activation of the vitamin D receptor when either vitamin D2 or D3 is added to the medium. Co-expression of CYP2R1 with vitamin D 1-hydroxylase CYP27B1 elicits additive activation of vitamin D3, whereas co-expression with vitamin D 24-hydroxylase CYP24A1 causes inactivation Mus musculus