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Literature summary extracted from
- Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes (2010), Int. J. Parasitol., 40, 533-542.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.21 | recombinantly expressed as a His-tagged fusion in Escherichia coli | Brugia malayi |
| 3.4.24.21 | recombinantly expressed as a His-tagged fusion in Escherichia coli | Haemonchus contortus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.21 | 1,10-phenanthroline | - |
Brugia malayi |  |
| 3.4.24.21 | 1,10-phenanthroline | - |
Haemonchus contortus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.21 | 50000 | - |
recombinant His-tagged protein | Brugia malayi |
| 3.4.24.21 | 50000 | - |
recombinant His-tagged protein | Haemonchus contortus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.21 | Brugia malayi | - |
- |
- |
| 3.4.24.21 | Caenorhabditis elegans | - |
- |
- |
| 3.4.24.21 | Haemonchus contortus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.21 | glycoprotein | putative | Brugia malayi |
| 3.4.24.21 | glycoprotein | putative | Haemonchus contortus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.21 | using Ni-NTA chromatography | Brugia malayi |
| 3.4.24.21 | using Ni-NTA chromatography | Haemonchus contortus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.21 | gut | - |
Caenorhabditis elegans | - |
| 3.4.24.21 | secretory cell | - |
Caenorhabditis elegans | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.21 | SQT-3 + H2O | - |
Brugia malayi | ? | - |
? | |
| 3.4.24.21 | SQT-3 + H2O | - |
Haemonchus contortus | ? | - |
? | |
| 3.4.24.21 | Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Brugia malayi | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| 3.4.24.21 | Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Caenorhabditis elegans | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| 3.4.24.21 | Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Haemonchus contortus | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.21 | DPY-31 | - |
Brugia malayi |
| 3.4.24.21 | DPY-31 | - |
Caenorhabditis elegans |
| 3.4.24.21 | DPY-31 | - |
Haemonchus contortus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.21 | 25 | - |
assay at | Brugia malayi |
| 3.4.24.21 | 25 | - |
assay at | Caenorhabditis elegans |
| 3.4.24.21 | 25 | - |
assay at | Haemonchus contortus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.21 | 8 | - |
assay at | Brugia malayi |
| 3.4.24.21 | 8 | - |
assay at | Caenorhabditis elegans |
| 3.4.24.21 | 8 | - |
assay at | Haemonchus contortus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.24.21 | malfunction | heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form | Caenorhabditis elegans |
| 3.4.24.21 | malfunction | heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form | Haemonchus contortus |
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Release 2023.1 (January 2023)
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