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Literature summary extracted from

  • Kudo, L.C.; Parfenova, L.; Ren, G.; Vi, N.; Hui, M.; Ma, Z.; Lau, K.; Gray, M.; Bardag-Gorce, F.; Wiedau-Pazos, M.; Hui, K.S.; Karsten, S.L.
    Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice (2011), Hum. Mol. Genet., 20, 1820-1833.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.14 expressed in Mus musculus Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.14 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.14 ion exchange chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.14 Leu-(beta-naphthylamine) + H2O
-
 Homo sapiens Leu + naphthylamine
-
 ?
3.4.11.14 Leu-4-methyl-coumaryl-7-amide + H2O
-
 Homo sapiens Leu + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.14 PSA/NPEPPS
-
 Homo sapiens
3.4.11.14 puromycin-sensitive aminopeptidase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.11.14 physiological function elevation of activity in vivo effectively blocks accumulation of soluble hyperphosphorylated TAU protein and slows down the progression of neurodegeneration in the mammalian system Homo sapiens