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Literature summary extracted from

  • Menzies, F.M.; Hourez, R.; Imarisio, S.; Raspe, M.; Sadiq, O.; Chandraratna, D.; OKane, C.; Rock, K.L.; Reits, E.; Goldberg, A.L.; Rubinsztein, D.C.
    Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy (2010), Hum. Mol. Genet., 19, 4573-4586.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.14 GFP fusion protein expressed in muscles of adult CD1 male mice and Drosophila Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.14 bestatin
-
 Homo sapiens
3.4.11.14 PAQ-22
-
 Homo sapiens
3.4.11.14 puromycin
-
 Homo sapiens
3.4.11.14 puromycin aminonucleoside
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.14 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.14 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.14 Ala-4-methyl-coumaryl-7-amide + H2O
-
 Homo sapiens Ala + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.14 puromycin-sensitive aminopeptidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.14 0.00007
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens bestatin
3.4.11.14 0.00008
-
 non-competitive, pH not specified in the publication, temperature not specified in the publication Homo sapiens PAQ-22
3.4.11.14 0.0006
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens puromycin
3.4.11.14 0.0025
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens puromycin aminonucleoside

General Information

EC Number General Information Comment Organism
3.4.11.14 malfunction decrease in activity increases the aggregation and toxicity of expanded huntingtin exon 1, overexpression reduces aggregates and toxicity of mutant huntingtin exon 1 Homo sapiens
3.4.11.14 physiological function suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo, decreases aggregate number in cellular models of neurodegenerative diseases, enhances macroautophagy Homo sapiens