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Literature summary extracted from

  • Vartapetian, A.B.; Tuzhikov, A.I.; Chichkova, N.V.; Taliansky, M.; Wolpert, T.J.
    A plant alternative to animal caspases: subtilisin-like proteases (2011), Cell Death Differ., 18, 1289-1297.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.62
-
 Solanum lycopersicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.62 additional information aldehyde and fluoromethyketone (FMK)-based inhibitors inhibit SAS-1 and -2 reversibly and only CMK-based inhibitors irreversibly inhibit the enzyme Avena sativa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.62 extracellular
-
 Avena sativa
-
-
3.4.21.62 extracellular extracellular in healthy tissues, shifts to cytoplasm upon programmed cell death induction Oryza sativa
-
-
3.4.21.62 extracellular extracellular in healthy tissues, shifts to cytoplasm upon programmed cell death induction Nicotiana tabacum
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.62 74500
-
 MALDI-TOF Avena sativa
3.4.21.62 80000
-
 single polypeptide chain Oryza sativa
3.4.21.62 80000
-
 single polypeptide chain Nicotiana tabacum
3.4.21.62 84000
-
 SDS-PAGE Avena sativa

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.62 Arabidopsis thaliana
-
 Arabidopsis genome contains 56 subtilase genes
-
3.4.21.62 Avena sativa
-
-
-
3.4.21.62 Glycine max
-
-
-
3.4.21.62 Nicotiana tabacum
-
-
-
3.4.21.62 Oryza sativa
-
-
-
3.4.21.62 Solanum lycopersicum
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.62 proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Avena sativa
3.4.21.62 proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Oryza sativa
3.4.21.62 proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Nicotiana tabacum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.62 additional information displays preference for cleavage after Glu Glycine max ?
-
 ?
3.4.21.62 additional information enzyme is able to hydrolyze a range of fluorogenic substrates, including AFC derivatives of VEID, VAD, YVAD, IETD, VDVAD and LEHD Oryza sativa ?
-
 ?
3.4.21.62 additional information enzyme is able to hydrolyze a range of fluorogenic substrates, including AFC derivatives of VEID, VAD, YVAD, IETD, VDVAD and LEHD Nicotiana tabacum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.62 ALE1 subtilase
-
 Arabidopsis thaliana
3.4.21.62 C1 subtilase
-
 Glycine max
3.4.21.62 P69 subtilase
-
 Solanum lycopersicum
3.4.21.62 phytophase extensive homology to other plant subtilisin-like serine protease, phytaspase: a plant aspartate-specific protease Oryza sativa
3.4.21.62 phytophase extensive homology to other plant subtilisin-like serine protease, phytaspase: a plant aspartate-specific protease Nicotiana tabacum
3.4.21.62 S1P subtilase
-
 Arabidopsis thaliana
3.4.21.62 SAS-1 extensive homology to other plant subtilisin-like serine protease Avena sativa
3.4.21.62 saspase saspase: serine proteases exhibting aspase activity Avena sativa
3.4.21.62 SDD1 subtilase
-
 Arabidopsis thaliana
3.4.21.62 SISBT3 subtilase
-
 Solanum lycopersicum

General Information

EC Number General Information Comment Organism
3.4.21.62 physiological function acts extracellularly in the apoplast of stomatal precursor cells where it may be involved in the generation of signals responsible for stomata density regulation Arabidopsis thaliana
3.4.21.62 physiological function the subtilase ALE1 is involved in the generation of peptide signals that are required for cuticle formation and epidermal differentiation during Arabidopsis embryo development Arabidopsis thaliana
3.4.21.62 physiological function implicated in fragmentation of the membrane-bound transcription factor AtbZIP1723 and precursors of pectin methylesterase and rapid alkalinization growth factor Arabidopsis thaliana
3.4.21.62 physiological function involved in proteolysis of the seed storage protein, beta-conglycinin Glycine max
3.4.21.62 physiological function pathogenesis related protein which is shown to be one of several subtilases that are specifically induced following pathogen infection. P69 is suggested to process a leucin-rich repeat cell wall protein in virus-infected tomato plants Solanum lycopersicum
3.4.21.62 physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. Enzyme is implicated the proteolytic degradation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) during biotic and abiotic programmed cell death Avena sativa
3.4.21.62 physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. In response to death-inducing stimuli, phytaspase is shown to re-localize to the cell interior Oryza sativa
3.4.21.62 physiological function enzyme shows caspase specificity Oryza sativa
3.4.21.62 physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. In response to death-inducing stimuli, phytaspase is shown to re-localize to the cell interior Nicotiana tabacum
3.4.21.62 physiological function enzyme shows caspase specificity Nicotiana tabacum