Literature summary extracted from

Camous, L.; Roumenina, L.; Bigot, S.; Brachemi, S.; Fremeaux-Bacchi, V.; Lesavre, P.; Halbwachs-Mecarelli, L.
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation (2011), Blood, 117, 1340-1349.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.47	formyl-methionyl-leucylphenylalanine	treatment of whole blood leads to stimulation of neutrophils resulting in activation of the alternative complement pathway and release of C5 fragments, which further amplify proinflammatory responses	Homo sapiens
3.4.21.47	phorbol myristate acetate	treatment of whole blood leads to stimulation of neutrophils resulting in activation of the alternative complement pathway and release of C5 fragments, which further amplify proinflammatory responses	Homo sapiens
3.4.21.47	tumor necrosis factor-alpha	treatment of whole blood leads to stimulation of neutrophils resulting in activation of the alternative complement pathway and release of C5 fragments, which further amplify proinflammatory responses	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.47	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.47	blood	-	Homo sapiens	-

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Release 2023.1 (January 2023)