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Literature summary extracted from
- Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins (2011), Biosci. Biotechnol. Biochem., 75, 1564-1569.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.23 | expression in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.23 | (-)-catechin-3-gallate | inhibition is un affected by presence of 10 mM CaCl2 | Homo sapiens |  |
| 3.4.24.23 | (-)-epicatechin-3-gallate | inhibition is un affected by presence of 10 mM CaCl2 | Homo sapiens | |
| 3.4.24.23 | (-)-epigallocatechin-3-gallate | inhibitory effect is increased on presence of 10 mM CaCl2, no interaction with Cl- | Homo sapiens | |
| 3.4.24.23 | (-)-gallocatechin-3-gallate | inhibitory effect is increased on presence of 10 mM CaCl2, no interaction with Cl- | Homo sapiens | |
| 3.4.24.23 | additional information | green tea catechins inhibit MMP-7 competitively and the galloyl group is essential, differences result from the B-ring, mechanism of inhibition | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.23 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.23 | recombinant enzyme from Escherichia coli | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.23 | (7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Gly-Leu-[N-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg amide + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.23 | Matrix metalloproteinase 7 | - |
Homo sapiens |
| 3.4.24.23 | MMP-7 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.23 | 25 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.23 | 7 | 8.5 | assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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