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Literature summary extracted from

  • Venkatraman, L.; Li, H.; Dewey Jr., C.; White, J.; Bhowmick, S.; Yu, H.; Tucker-Kellogg, L.
    Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro (2011), Biophys. J., 101, 1825-1834.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.73 additional information plasmin and urokinase-type plasminogen activator can activate each other through proteolytic cleavage Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.7 additional information
-
 additional information although neither plasmin nor urokinase-type plasminogen activator exhibits allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition, molecular modeling and simulation, substrate competition and bistability, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.73 extracellular secreted in inactive form Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.7 Homo sapiens
-
-
-
3.4.21.73 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.7 proteolytic modification cleavage of plasminogen to active plasmin by urokinase-type plasminogen activator, complex dynamics and mathematical modeling, overview Homo sapiens
3.4.21.73 proteolytic modification secretion in inactive forms, and activation by plasmin through proteolytic cleavage, mathematical modeling, overview Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.7 commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.7 D-Val-Leu-Lys-4-nitroanilide + H2O
-
 Homo sapiens D-Val-Leu-Lys + 4-nitroaniline
-
 ?
3.4.21.7 additional information substrate competition with urokinase-type plasminogen activator and bistability, overview Homo sapiens ?
-
 ?
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.7 PLS
-
 Homo sapiens
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase
-
 Homo sapiens
3.4.21.73 Urokinase-type plasminogen activator
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.7 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.7 physiological function plasmin and urokinase-type plasminogen activator are ubiquitous proteases that regulate the extracellular environment. Although neither plasmin nor urokinase-type plasminogen activator exhibits allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition Homo sapiens
3.4.21.73 physiological function plasmin and urokinase-type plasminogen activator are ubiquitous proteases that regulate the extracellular environment and activate each other through proteolytic cleavage. Although neither plasmin nor urokinase-type plasminogen activator exhibit allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition, computational simulations and bifurcation analysis, overview. Ultrasensitive, bistable activation of UPA-PLS is possible in the presence of substrate competition Homo sapiens