Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pascale, R.; Carocci, A.; Catalano, A.; Lentini, G.; Spagnoletta, A.; Cavalluzzi, M.M.; De Santis, F.; De Palma, A.; Scalera, V.; Franchini, C.
    New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase (2010), Bioorg. Med. Chem., 18, 5903-5914.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 1-deoxynojirimycin
-
 Saccharomyces cerevisiae
3.2.1.20 2-(10-phenoxydecyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(2-phenoxyethyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(3-phenoxypropyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(4-phenoxybutyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(5-phenoxypentyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(6-phenoxyhexyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(8-phenoxyoctyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-(9-phenoxynonyl)-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2,4-dichloro-6-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2,4-dichlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2,4-dinitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2,6-dimethyl-4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2,6-dimethylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(3,4-dichlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(3-chlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(3-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4,5-dichloro-2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-chloro-2,6-dimethyl-3-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-chloro-2,6-dimethylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-chloro-2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-chlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-methylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(5-chloro-2-methyl-4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-(5-chloro-2-methylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-[2-nitro-4-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-[4-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[10-[4-nitro-3-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[2-(4-chloro-2,6-dimethylphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[2-(4-chloro-2-methylphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[2-(4-chlorophenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[3-(2,3-dichlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[3-(3,4-dichlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[3-(4-chloro-2,6-dimethylphenoxy)propyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[3-(4-chloro-2-methylphenoxy)propyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 2-[3-(4-chlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
-
 Saccharomyces cerevisiae
3.2.1.20 additional information synthesis of a series of non-sugar-type alpha-glucosidase inhibitors, bearing a phthalimide moiety connected to a variously substituted phenoxy ring by an alkyl chain, efficacy of the inhibition activity appears to be governed by the chain length of the substrate. Derivatives bearing a chlorine atom along with a strong electron-withdrawing group, such as a nitro group, are the most potent of the series Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.20 commercial preparation
-
 Saccharomyces cerevisiae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Saccharomyces cerevisiae 4-nitrophenol + alpha-D-glucopyranose
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.20 37
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.20 7.3
-
 assay at Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.20 0.00048
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-chloro-2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00052
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4,5-dichloro-2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00065
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(5-chloro-2-methyl-4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00075
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2,4-dichloro-6-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00083
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-[4-nitro-3-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00083
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-[4-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00086
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00091
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(5-chloro-2-methylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00097
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2,4-dinitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.001
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(3,4-dichlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.001075
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(3-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00109
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(3-chlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00119
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2,4-dichlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0012
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-chlorophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00131
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-[2-nitro-4-(trifluoromethyl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00132
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2,6-dimethyl-4-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00134
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-chloro-2,6-dimethylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00178
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0021
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-methylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0025
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(10-phenoxydecyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00304
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(9-phenoxynonyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.00325
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(2,6-dimethylphenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0036
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[10-(4-chloro-2,6-dimethyl-3-nitrophenoxy)decyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0065
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(8-phenoxyoctyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0076
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[3-(3,4-dichlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0089
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[3-(4-chloro-2-methylphenoxy)propyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0095
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[3-(4-chloro-2,6-dimethylphenoxy)propyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0103
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(6-phenoxyhexyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.013
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[2-(4-chloro-2,6-dimethylphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0148
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[2-(4-chloro-2-methylphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.015
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[3-(2,3-dichlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.0202
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(5-phenoxypentyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.033
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(4-phenoxybutyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.059
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[3-(4-chlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.094
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-[2-(4-chlorophenoxy)ethyl]-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.24
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(3-phenoxypropyl)-1H-isoindole-1,3(2H)-dione
3.2.1.20 0.296
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae 2-(2-phenoxyethyl)-1H-isoindole-1,3(2H)-dione