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Literature summary extracted from

  • Kantyka, T.; Plaza, K.; Koziel, J.; Florczyk, D.; Stennicke, H.R.; Thogersen, I.B.; Enghild, J.J.; Silverman, G.A.; Pak, S.C.; Potempa, J.
    Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence (2011), Biol. Chem., 392, 483-489.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.48 squamous cell carcinoma antigen 1 the high association rate constant (kass) for inhibitory complex formation (19000 M/s for staphopain A interaction with SCCA1) suggests that squamous cell carcinoma antigen 1 (SCCA1) can regulate staphopain activity in vivo at epithelial surfaces infected/colonized by Staphylococcu aureus; the high association rate constant (kass) for inhibitory complex formation (58000 M/s for staphopain A interaction with SCCA1) suggests that squamous cell carcinoma antigen 1 (SCCA1) can regulate staphopain activity in vivo at epithelial surfaces infected/colonized by Staphylococcu aureus Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.48 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.48 Abz-Glu-Ala-Leu-Gly-Thr-Ser-Pro-Arg-Lys(Dnp)-Asp + H2O
-
 Staphylococcus aureus ?
-
 ?
3.4.22.48 Abz-Glu-Gly-Ile-Gly-Thr-Ser-Arg-Pro-Lys(Dnp)-Asp + H2O
-
 Staphylococcus aureus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.48 staphopain A
-
 Staphylococcus aureus
3.4.22.48 staphopain B
-
 Staphylococcus aureus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.48 37
-
 assay at Staphylococcus aureus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.48 7.6
-
 assay at Staphylococcus aureus