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Literature summary extracted from

  • Hook, V.; Funkelstein, L.; Wegrzyn, J.; Bark, S.; Kindy, M.; Hook, G.
    Cysteine cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimers disease (2012), Biochim. Biophys. Acta, 1824, 89-104.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 CLIK-148 specific inhibitor of cathepsin L Mus musculus
3.4.22.15 E-64
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.15 secretory vesicle
-
 Mus musculus 99503
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.15 BAM-22P + H2O Mus musculus
-
 (Met)enkephalin + ?
-
 ?
3.4.22.15 Cholecystokinin + H2O Mus musculus
-
 ?
-
 ?
3.4.22.15 chromogranin A + H2O Mus musculus
-
 catestatin
-
 ?
3.4.22.15 pro-dynorphin + H2O Mus musculus
-
 ?
-
 ?
3.4.22.15 pro-enkephalin + H2O Mus musculus
-
 enkephalin + ?
-
 ?
3.4.22.15 Pro-opiomelanocortin + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 BAM-22P + H2O
-
 Mus musculus (Met)enkephalin + ?
-
 ?
3.4.22.15 Cholecystokinin + H2O
-
 Mus musculus ?
-
 ?
3.4.22.15 chromogranin A + H2O
-
 Mus musculus catestatin
-
 ?
3.4.22.15 pro-dynorphin + H2O
-
 Mus musculus ?
-
 ?
3.4.22.15 pro-enkephalin + H2O
-
 Mus musculus enkephalin + ?
-
 ?
3.4.22.15 Pro-opiomelanocortin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.15 CatL
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.15 malfunction in cathepsin L knockou mice, brain levels of (Met)enkephalin are reduced to 44%, brain levels of neuropeptide Y are reduced to 22%, brain levels of cholecystokinin are reduced to 75%, brain levels of dynorphin A are reduced to 25% , brain levels of dynorphin B are reduced to 17%, brain levels of alpha-neoendorphin are reduced to 10%, brain levels of adrenocorticotropin hormone are reduced to 23%, brain levels of beta-endorphin are reduced to 18%, and brain levels of alpha-MSH are reduced to 7% of the wild type level Mus musculus
3.4.22.15 physiological function cathepsin L in secretory vesicles functions as a key protease for proteolytic processing of proneuropeptides (including enkephalin, neuropeptide Y, dynorphins, cholecystokinin, and others) and prohormones into active neuropeptides that are released to mediate cell-cell communication in the nervous system for neurotransmission. Cathepsin L is a key protease responsible for cholecystokinin 8 production in brain Mus musculus