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Literature summary extracted from
- Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite (2005), Biochim. Biophys. Acta, 1722, 304-311.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.56 | expression in Escherichia coli | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.56 | 0.012 | - |
1,8-cineole | pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4 | Homo sapiens |  |
| 1.14.14.56 | 0.019 | - |
1,8-cineole | pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4 | Homo sapiens | |
| 1.14.14.56 | 0.141 | - |
1,8-cineole | pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A5 | Homo sapiens | |
| 1.14.14.56 | 0.599 | - |
1,8-cineole | pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A5 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.56 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.56 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.56 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.56 | 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Homo sapiens | 2alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.56 | 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Homo sapiens | 3alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.56 | CYP3A4 | - |
Homo sapiens |
| 1.14.14.56 | CYP3A5 | - |
Homo sapiens |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.56 | 0.056 | - |
1,8-cineole | pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4 | Homo sapiens | |
| 1.14.14.56 | 0.08 | - |
1,8-cineole | pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4 | Homo sapiens | |
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