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Literature summary extracted from

  • Peltonen, I.; Maennistoe, P.T.
    Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase (2011), Basic Clin. Pharmacol. Toxicol., 108, 46-54.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 buspirone 25% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 chlorpromazine 55% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 citalopram 27% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 clozapine 40% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 desipramine 20% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 duloxetine 21% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 escitalopram 39% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 flupenthixol 56% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 imipramine 29% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 ketanserin mixed type inhibitor, 49% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 lamotrigine 22% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 levomepromazine 32% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 mianserin 15% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 additional information not inhibited by carbamazepine, bupropion, diazepam, fluoxetine, haloperidol, lithium, maprotiline, mirtazapine, moclobemide, pargyline, pinoline, scopolamine, selegiline, sulpiride, venlafaxine, and valpraote at 0.01 mM concentration Rattus norvegicus
3.4.21.26 pimozide 11% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 prazosin 91% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 prochlorperazine 77% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 promazine 64% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 reboxetine 13% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 reserpine 18% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 risperidone 56% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 ritanserin 33% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 thioridazine non-competitive inhibitor, 91% inhibition at 0.01 mM Rattus norvegicus
3.4.21.26 Valproate competitive inhibitor, 56% inhibition at 0.5 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 POP
-
 Rattus norvegicus