Literature summary extracted from

Udenigwe, C.; Li, H.; Aluko, R.
Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides (2011), Amino Acids, 2011, 1-8.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.23.15	L-Ile-L-Trp	70% inhibition at 3.2 mM	Homo sapiens
3.4.23.15	L-Leu-L-Trp	37% inhibition at 3.2 mM	Homo sapiens
3.4.23.15	additional information	not inhibited by L-Val-L-Trp and L-Ala-L-Trp	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.15	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.15	angiotensinogen + H2O	-	Homo sapiens	angiotensin I + angiotensinogen propeptide	-	?

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.4.23.15	2.3	-	recombinant enzyme, in 50 mM Tris-HCl buffer containing 100 mM NaCl (pH 8.0), at 37°C	Homo sapiens	L-Ile-L-Trp

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Release 2023.1 (January 2023)