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Literature summary extracted from

  • Braber, S.; Koelink, P.J.; Henricks, P.A.; Jackson, P.L.; Nijkamp, F.P.; Garssen, J.; Kraneveld, A.D.; Blalock, J.E.; Folkerts, G.
    Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown (2011), Am. J. Physiol. Lung Cell Mol. Physiol., 300, L255-L265.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.26 Collagen + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 lung highly expressed in lung tissue of cigarette smoke-exposed mice Mus musculus
-
3.4.21.26 macrophage
-
 Mus musculus
-
3.4.21.26 neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 Collagen + H2O
-
 Mus musculus ?
-
 ?
3.4.21.26 Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 prolyl endopeptidase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.21.26 Mus musculus prolyl endopeptidas activity is 2fold elevated in the lungs of cigarette smoke-exposed mice up

General Information

EC Number General Information Comment Organism
3.4.21.26 metabolism prolyl endopeptidase is involved in collagen breakdown Mus musculus
3.4.21.26 physiological function cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase Mus musculus