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Literature summary extracted from
- T2 Family ribonucleases: ancient enzymes with diverse roles (2010), Trends Biochem. Sci., 35, 253-259.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.19 | extracellular | the enzyme is secreted | Entamoeba histolytica | - |
- |
| 4.6.1.19 | extracellular | the enzyme is secreted | Schistosoma mansoni | - |
- |
| 4.6.1.19 | extracellular | the enzyme is secreted | Bovine viral diarrhea virus 1 | - |
- |
| 4.6.1.19 | extracellular | the enzyme is secreted | Classical swine fever virus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.19 | additional information | Homo sapiens | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | ? | - |
? |  |
| 4.6.1.19 | additional information | Entamoeba histolytica | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | ? | - |
? | |
| 4.6.1.19 | additional information | Schistosoma mansoni | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | ? | - |
? | |
| 4.6.1.19 | additional information | Aspergillus oryzae | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | ? | - |
? | |
| 4.6.1.19 | additional information | Rhizopus niveus | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.19 | Aspergillus niger | - |
gene RNASET2 | - |
| 4.6.1.19 | Aspergillus oryzae | - |
gene RNASET2 | - |
| 4.6.1.19 | Bovine viral diarrhea virus 1 | - |
BVDV | - |
| 4.6.1.19 | Classical swine fever virus | - |
CSFV | - |
| 4.6.1.19 | Entamoeba histolytica | - |
gene RNASET2 | - |
| 4.6.1.19 | Homo sapiens | - |
gene RNASET2 | - |
| 4.6.1.19 | Rhizopus niveus | - |
gene RNASET2 | - |
| 4.6.1.19 | Schistosoma mansoni | - |
gene RNASET2 | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 4.6.1.19 | glycoprotein | - |
Bovine viral diarrhea virus 1 |
| 4.6.1.19 | glycoprotein | - |
Classical swine fever virus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.19 | additional information | during a human infection this worm lays its eggs in its definitive mammalian host, and these eggs secrete a factor termed omega-1, which is a known RNaseT2 family member | Schistosoma mansoni | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.19 | additional information | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | Homo sapiens | ? | - |
? | |
| 4.6.1.19 | additional information | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | Entamoeba histolytica | ? | - |
? | |
| 4.6.1.19 | additional information | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | Schistosoma mansoni | ? | - |
? | |
| 4.6.1.19 | additional information | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | Aspergillus oryzae | ? | - |
? | |
| 4.6.1.19 | additional information | the enzyme catalyzes the cleavage of ssRNA through a 2',3'-cyclic phosphate intermediate, producing mono- or oligonucleotides with a terminal 3' phosphate group | Rhizopus niveus | ? | - |
? | |
| 4.6.1.19 | additional information | the enzyme ACTIBIND is able to bind actin in vitro | Aspergillus niger | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.6.1.19 | More | the enzyme shows a conserved alpha/beta core structure, identification of substrate binding regions, overview | Rhizopus niveus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.19 | ACTIBIND | - |
Aspergillus niger |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Homo sapiens |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Aspergillus niger |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Entamoeba histolytica |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Schistosoma mansoni |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Aspergillus oryzae |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Rhizopus niveus |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Bovine viral diarrhea virus 1 |
| 4.6.1.19 | More | the enzyme belongs to the RNaseT2 enzyme family | Classical swine fever virus |
| 4.6.1.19 | omega-1 | - |
Schistosoma mansoni |
| 4.6.1.19 | ribonuclease Rh | - |
Rhizopus niveus |
| 4.6.1.19 | RNaseT2 | - |
Homo sapiens |
| 4.6.1.19 | RNaseT2 | - |
Aspergillus niger |
| 4.6.1.19 | RNaseT2 | - |
Entamoeba histolytica |
| 4.6.1.19 | RNaseT2 | - |
Schistosoma mansoni |
| 4.6.1.19 | RNaseT2 | - |
Aspergillus oryzae |
| 4.6.1.19 | RNaseT2 | - |
Rhizopus niveus |
| 4.6.1.19 | RNaseT2 | - |
Bovine viral diarrhea virus 1 |
| 4.6.1.19 | RNaseT2 | - |
Classical swine fever virus |
| 4.6.1.19 | T2 ribonuclease | - |
Aspergillus niger |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.6.1.19 | malfunction | RNaseT2 family members are implicated in human pathologies such as cancer and parasitic diseases. Humans lacking RNASET2 manifest a defect in neurological development, perhaps due to aberrant control of the immune system. Mutations in RNASET2 are identified as the causative lesion in an autosomal recessive disorder leading to cystic leukoencephalopathy, overview | Homo sapiens |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Homo sapiens |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Aspergillus niger |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Entamoeba histolytica |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Schistosoma mansoni |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Aspergillus oryzae |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Rhizopus niveus |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Bovine viral diarrhea virus 1 |
| 4.6.1.19 | additional information | comparisons of basic structure and function of RNaseT2 family members and their biological roles. Ribonucleases of the T2 family are transferase-type RNases and are classified by their similarity to the RNase T2 protein from Aspergillus oryzae | Classical swine fever virus |
| 4.6.1.19 | physiological function | ACTIBIND inhibits the clonogenicity and invasiveness of various tumors in culture and in mouse models. ACTIBIND disrupts the fine actin networks at the interior of colon cancer cells. Interaction of RNaseT2 proteins with the actin cytoskeleton provides a possible mechanism for RNase-independent cytotoxicity | Aspergillus niger |
| 4.6.1.19 | physiological function | RNaseT2 omega-1 is the major component in priming dendritic cells for Th2 polarization of CD4+ T cells during infection, a process depending on the RNase activity of omega-1 | Schistosoma mansoni |
| 4.6.1.19 | physiological function | RNaseT2 protein secreted by the purine auxotroph Entamoeba histolytica might function in scavenging purines from this amoeba's host | Entamoeba histolytica |
| 4.6.1.19 | physiological function | the envelope glycoprotein, termed Erns, has an RNaseT2 domain and ribonuclease activity, and is secreted by infected cells, the RNaseT2 protein induces cytotoxicity against host lymphocytes, but not epithelial cells, of various host species, and modulates host immune cell function | Bovine viral diarrhea virus 1 |
| 4.6.1.19 | physiological function | the envelope glycoprotein, termed Erns, has an RNaseT2 domain and ribonuclease activity, and is secreted by infected cells, the RNaseT2 protein induces cytotoxicity against host lymphocytes, but not epithelial cells, of various host species, and modulates host immune cell function | Classical swine fever virus |
| 4.6.1.19 | physiological function | the enzyme has a role in neural development | Homo sapiens |
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