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Literature summary extracted from

  • Prosser, D.E.; Jones, G.
    Enzymes involved in the activation and inactivation of vitamin D (2004), Trends Biochem. Sci., 29, 664-673.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.16 mitochondrion
-
 Mus musculus 5739
-
1.14.15.16 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Homo sapiens
-
-
-
1.14.15.16 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.16 kidney the enzyme is absent from the liver and osteoclasts Mus musculus
-
1.14.15.16 kidney the enzyme is absent from the liver and osteoclasts Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2
-
 Mus musculus calcitroic acid + NADP+ + ?
-
 ?
1.14.15.16 1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2
-
 Homo sapiens calcitroic acid + NADP+ + ?
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 calcidiol + NADPH + H+ + O2
-
 Mus musculus secalciferol + NADP+ + H2O
-
 ?
1.14.15.16 calcidiol + NADPH + H+ + O2
-
 Homo sapiens secalciferol + NADP+ + H2O
-
 ?
1.14.15.16 calcitriol + NADPH + H+ + O2
-
 Mus musculus calcitetrol + NADP+ + H2O
-
 ?
1.14.15.16 calcitriol + NADPH + H+ + O2
-
 Homo sapiens calcitetrol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 25-OH-D3-24-hydroxylase
-
 Mus musculus
1.14.15.16 25-OH-D3-24-hydroxylase
-
 Homo sapiens
1.14.15.16 CYP24A1
-
 Mus musculus
1.14.15.16 CYP24A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Mus musculus
1.14.15.16 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.15.16 Mus musculus CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 up
1.14.15.16 Homo sapiens CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 up

General Information

EC Number General Information Comment Organism
1.14.15.16 malfunction the Cyp24a1 knockout mouse is consistent with a catabolic role for CYP24A1, because it shows poor viability, 50% of homozygous mice die before weaning, showing hypercalcemia and signs of renal calcification. Isolated cultured keratinocytes from Cyp24a1-deficient mice fail to synthesize calcitroic acid Mus musculus
1.14.15.16 physiological function CYP24A1 has a crucial role in vitamin D inactivation in vivo Mus musculus
1.14.15.16 physiological function CYP24A1 has a crucial role in vitamin D inactivation in vivo Homo sapiens