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Literature summary extracted from

  • King, C.R.; Deych, E.; Milligan, P.; Eby, C.; Lenzini, P.; Grice, G.; Porche-Sorbet, R.M.; Ridker, P.M.; Gage, B.F.
    Gamma-glutamyl carboxylase and its influence on warfarin dose (2010), Thromb. Haemost., 104, 750-754.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.90 medicine single nucleotide polymorphism in the GGCX gene may affect the dose of warfarin and other vitamin K antagonists Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.90 additional information GGCX single nucleotide polymorphism rs11676382(but not rs12714145) is a significant predictor of residual warfarin dosing error and is associated with a 6.1% reduction in warfarin dose per G allele Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.90 endoplasmic reticulum membrane
-
 Homo sapiens 5789
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.90 L-glutamate + CO2 + O2 + vitamin K hydroquinone Homo sapiens
-
 gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
 Homo sapiens gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 gamma-glutamyl carboxylase
-
 Homo sapiens
4.1.1.90 GGCX
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 vitamin K
-
 Homo sapiens