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Literature summary extracted from

  • Foster, M.; Oldham, C.; May, S.
    Looking glass mechanism-based inhibition of peptidylglycine alpha-amidating monooxygenase (2011), Tetrahedron Asymmetry, 22, 283-293.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.17.3 expressed in Sf9 cell Xenopus laevis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.3 (R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid reversible and irreversible inhibition Xenopus laevis
1.14.17.3 (S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid reversible and irreversible inhibition Xenopus laevis
1.14.17.3 (S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid reversible and irreversible inhibition Xenopus laevis
1.14.17.3 N-acetyl-D-Leu-OCH2COOH competitive inhibitor Xenopus laevis
1.14.17.3 N-acetyl-D-Phe-Gly
-
 Xenopus laevis
1.14.17.3 N-acetyl-L-Leu-OCH2COOH competitive inhibitor Xenopus laevis
1.14.17.3 N-acetyl-L-Phe-OCH2COOH competitive inhibitor Xenopus laevis
1.14.17.3 O-acetyl-D-mandelyl-Gly
-
 Xenopus laevis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.3 0.0079
-
 N-acetyl-L-Phe-Gly pH not specified in the publication, temperature not specified in the publication Xenopus laevis
1.14.17.3 0.17
-
 O-acetyl-L-mandelyl-Gly pH not specified in the publication, temperature not specified in the publication Xenopus laevis

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.3 cation-exchange chromatography, anion-exchange chromatography, gel filtration Xenopus laevis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.3 skin
-
 Xenopus laevis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 N-acetyl-L-Phe-Gly + ascorbate + O2
-
 Xenopus laevis N-acetyl-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
 ?
1.14.17.3 O-acetyl-L-mandelyl-Gly + ascorbate + O2
-
 Xenopus laevis O-acetyl-L-mandelyl-2-hydroxyglycine + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2
-
 Xenopus laevis peptidyl (S)-2-hydroxyglycine + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.3 peptidylglycine alpha-monooxygenase
-
 Xenopus laevis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.3 0.0452
-
 N-acetyl-L-Phe-OCH2COOH pH not specified in the publication, temperature not specified in the publication Xenopus laevis
1.14.17.3 0.054
-
 (S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid pH 6.5, 37°C Xenopus laevis
1.14.17.3 0.057
-
 (S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid pH 6.5, 37°C Xenopus laevis
1.14.17.3 0.0598
-
 N-acetyl-L-Leu-OCH2COOH pH not specified in the publication, temperature not specified in the publication Xenopus laevis
1.14.17.3 0.06
-
 (R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid pH 6.5, 37°C Xenopus laevis
1.14.17.3 1.3
-
 N-acetyl-D-Phe-Gly pH not specified in the publication, temperature not specified in the publication Xenopus laevis
1.14.17.3 2.1
-
 N-acetyl-D-Leu-OCH2COOH pH not specified in the publication, temperature not specified in the publication Xenopus laevis
1.14.17.3 8.1
-
 O-acetyl-D-mandelyl-Gly pH not specified in the publication, temperature not specified in the publication Xenopus laevis